Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies.
Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies.
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DOI：
10.1111/j.1471-4159.2010.06993.x
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发表时间：
2010-11
影响因子：
4.7
通讯作者：
Murphy SP
中科院分区：
文献类型：
--
作者：
Gibson CL;Murphy SP
抑制组蛋白去乙酰化酶（HDAC）活性的药物作为神经保护剂具有巨大的潜力。我们对在急性脑损伤之前和/或之后给予锌依赖性HDAC的已知抑制剂的对照动物研究进行了系统回顾，并评估了解剖/功能结局。通过检索PubMed、Embase和Web of Science，查找相关文献。使用科克伦综述管理器软件对100多篇已识别出版物中符合特定标准的数据进行分析。在涉及脑缺血或急性脑损伤的非缺血模型的研究中观察到给予HDAC抑制剂的有益效果。特定研究评估了在脑损伤发作前14天和脑损伤发作后14天内给药的疗效。这篇系统性综述为抑制HDAC的药物的神经保护作用提供了客观证据，并强调了需要进一步实验研究的特定领域。
Drugs that inhibit histone deacetylase (HDAC) activities have enormous potential as neuroprotective agents. We performed a systematic review of controlled animal studies that administered known inhibitors of the zinc-dependent HDACs before and/or after acute cerebral injury and assessed anatomic/functional outcomes. Relevant studies were found by searching PubMed, Embase and Web of Science. From more than 100 identified publications, those data meeting specific criteria were analyzed using the Cochrane Review Manager software. A beneficial effect of administering HDAC inhibitors was seen in studies involving cerebral ischemia or non-ischemic models of acute cerebral injury. Specific studies assessed efficacy when drug was administered up to 14 days prior to, and 14 days following, the onset of cerebral injury. This systematic review provides objective evidence of a neuroprotective role for drugs that inhibit HDACs and highlights particular areas that require further experimental investigation.
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影响因子：
5.7
作者：
Lee, Seunghee;Lee, Soo-Kyung
通讯作者：
Lee, Soo-Kyung
影响因子：
25
作者：
Kim, Jin Young;Shen, Siming;Dietz, Karen;He, Ye;Howell, Owain;Reynolds, Richard;Casaccia, Patrizia
通讯作者：
Casaccia, Patrizia
DOI：
10.1124/jpet.107.120188
发表时间：
2007-06-01
影响因子：
3.5
作者：
Kim, Hyeon Ju;Rowe, Michael;Chuang, De-Maw
通讯作者：
Chuang, De-Maw
影响因子：
15.9
作者：
Chuang, De-Maw;Leng, Yan;Marinova, Zoya;Kim, Hyeon-Ju;Chiu, Chi-Tso
通讯作者：
Chiu, Chi-Tso
影响因子：
4.7
作者：
Kim HJ;Leeds P;Chuang DM
通讯作者：
Chuang DM