Intramitochondrial phospholipid trafficking.
Intramitochondrial phospholipid trafficking.
复制标题
DOI：
10.1016/j.bbalip.2016.08.006
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
T. Tatsuta;T. Langer
中科院分区：
文献类型：
--
作者：
T. Tatsuta;T. Langer
线粒体的功能和结构依赖于其外膜和内膜的确定的脂质组成，其特征在于高含量的非双层磷脂，如心磷脂（CL）和磷脂酰乙醇胺（PE）。线粒体膜脂质在内质网（ER）中或在线粒体内从ER衍生的前体脂质合成，在线粒体内不对称分布，并且可以响应于细胞应激而重新定位。因此，脂质稳态的维持需要在线粒体内协调多个脂质转运过程。最近的研究发现，Ups/PRELI家族成员作为线粒体中的特异性脂质转移蛋白，在线粒体膜之间穿梭磷脂。它们与膜组织蛋白合作，保护线粒体膜的空间组织和膜接触位点的形成，解开膜脂质运输和稳态与线粒体结构组织的亲密串扰。
Mitochondrial functions and architecture rely on a defined lipid composition of their outer and inner membranes, which are characterized by a high content of non-bilayer phospholipids such as cardiolipin (CL) and phosphatidylethanolamine (PE). Mitochondrial membrane lipids are synthesized in the endoplasmic reticulum (ER) or within mitochondria from ER-derived precursor lipids, are asymmetrically distributed within mitochondria and can relocate in response to cellular stress. Maintenance of lipid homeostasis thus requires multiple lipid transport processes to be orchestrated within mitochondria. Recent findings identified members of the Ups/PRELI family as specific lipid transfer proteins in mitochondria that shuttle phospholipids between mitochondrial membranes. They cooperate with membrane organizing proteins that preserve the spatial organization of mitochondrial membranes and the formation of membrane contact sites, unravelling an intimate crosstalk of membrane lipid transport and homeostasis with the structural organization of mitochondria.This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.