Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma.
Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma.
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Cbx4表达的预后意义及其对肝细胞癌经动脉化疗栓塞术的有益作用
DOI：
10.1038/cddis.2015.57
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发表时间：
2015-03-12
影响因子：
9
通讯作者：
中科院分区：
文献类型：
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作者：
我们最近的研究发现多梳状染色体盒4（Polycomb chromobox 4，Cbx 4）通过对低氧诱导因子-1 α（hypoxia-inducible factor-1α，HIF-1α）蛋白的SUMO化作用促进肝细胞癌（hepatocellular carcinoma，HCC）的血管生成和转移。在此，我们试图通过对727例肝细胞癌患者进行回顾性分析，以确定Cbx 4的预后意义，这些患者有或没有术后经动脉化疗栓塞（TACE）或经动脉栓塞（TAE）。Logistic回归分析显示，Cbx 4与HCC的组织学分级、淋巴结转移分期、微血管密度、远处转移和血行转移相关。通过单因素和多因素分析，我们发现Cbx 4是HCC的独立预后因素，TAE和TACE治疗对Cbx 4低表达的HCC患者的总生存率没有影响。更有趣的是，TACE缩短了具有高Cbx 4表达的HCC患者的总生存期，而TAE缩短了总生存期，这表明Cbx 4是HCC患者进行术后TACE决策的良好生物标志物。此外，Cbx 4过表达增强，而Cbx 4沉默拮抗阿霉素诱导的肝癌细胞系的细胞死亡。结论：Cbx 4是影响肝癌患者预后的独立因素，Cbx 4高表达的患者应接受术后TACE治疗以提高生存率。
Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastasis of hepatocellular carcinoma (HCC) through its sumoylating action on hypoxia-inducible factor-1α protein. Here, we attempt to identify the prognostic significances of Cbx4 by a retrospective analyses in 727 cases of HCC patients with and without postoperative transarterial chemoembolization (TACE) or transarterial embolization (TAE). Binary logistic regression tests indicated that Cbx4 is correlated with histological grading, tumor-node-metastasis stage, microvessel density, distant metastasis and hematogenous metastasis of HCC. By univariate and multivariate analyses, we show that Cbx4 is an independent prognostic factor of HCC, and both TAE and TACE treatments have no effects on the overall survival in HCC patients with low Cbx4 expression. More intriguingly, TACE prolongs, while TAE shortens, the overall survival of HCC patients with high Cbx4 expression, indicating that Cbx4 is a good biomarker on decision-making to perform postoperative TACE in HCC patients. Moreover, Cbx4 overexpression enhances while Cbx4 silencing antagonizes doxorubicin-induced cell death of HCC cell lines. In conclusion, Cbx4 is an independent prognostic factor for HCC patients, and the patients with high Cbx4 expression should receive postoperative TACE treatment to improve their survival.
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