Cost analysis and efficacy of recruitment strategies used in a large pragmatic community-based clinical trial targeting low-income seniors: a comparative descriptive analysis
Cost analysis and efficacy of recruitment strategies used in a large pragmatic community-based clinical trial targeting low-income seniors: a comparative descriptive analysis
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DOI：
10.1186/s13063-019-3652-5
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发表时间：
2019-10-07
期刊：
影响因子：
2.5
通讯作者：
Campbell, David J. T.
中科院分区：
文献类型：
--
作者：
Kakumanu, Sravya;Manns, Braden J.;Campbell, David J. T.
目的临床试验最具挑战性的部分之一是招募足够的受试者。我们的目标是确定哪些招募策略在达到特定亚组方面是有效的。研究设计和设置我们评估了在加拿大阿尔伯塔通过患者教育和基于价值的处方集研究（ACCESS）评估增强慢性病护理的结果中使用的招募策略的有效性和成本。结果研究预算的20%（354，330加元）用于招募4013名参与者，平均每位入组者的费用为88加元。药房招募了最多的参与者（n = 1217），费用为128美元/人。“付费媒体”的成本最高（806美元/注册），而“口碑”和“免费媒体”的成本最低（类似于3美元/注册）。从“老年人外展”招募的参与者的生活质量和收入基线最低，而从“口口相传”招募的参与者的教育程度最低。结论：“卫生保健提供者”的战略是特别成功的-在一个适度的成本每注册。“媒体”战略效果较差，持续时间较短，成本较高。没有一种策略在招募我们的目标群体时特别有效，强调了利用各种策略来实现招募目标的重要性。
Objective One of the most challenging parts of running clinical trials is recruiting enough participants. Our objective was to determine which recruitment strategies were effective in reaching specific subgroups. Study design and setting We assessed the efficacy and costs of the recruitment strategies used in the Assessing Outcomes of Enhanced Chronic Disease Care Through Patient Education and a Value-based Formulary Study (ACCESS) in Alberta, Canada. Results Twenty percent of the study budget ($354,330 CAD) was spent on recruiting 4013 participants, giving an average cost per enrolled of $88 CAD. Pharmacies recruited the most participants (n = 1217), at a cost of $128/enrolled. "Paid media" had the highest cost ($806/enrolled), whereas "word of mouth" and "unpaid media" had the lowest (similar to$3/enrolled). Participants enrolled from "seniors outreach" had the lowest baseline quality of life and income, while participants from "word of mouth" had the lowest educational attainment. Conclusion The "health care providers" strategies were especially successful - at a moderate cost per enrolled. The "media" strategies were less effective, short lasting, and more costly. No strategy was singularly effective in recruiting our targeted groups, emphasizing the importance of utilizing a variety of strategies to reach recruitment goals.