Environmental exposures and development.
Environmental exposures and development.
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DOI：
10.1097/mop.0b013e32833779bf
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发表时间：
2010-04
影响因子：
3.6
通讯作者：
Mattison DR
中科院分区：
文献类型：
--
作者：
Mattison DR
总结最近的研究，探讨父亲和母亲在受孕前、受孕时和受孕后接触化学物质的环境与不良发育结果之间的关系，包括：早产、死亡、结构和功能异常以及生长受限。最近的研究表明，人类怀孕和发育很容易受到父亲和母亲接触化学、生物和物理因素的环境影响。与不良发育结果相关的暴露包括：空气和水污染、食品中的化学物质、职业暴露、农业化学品、金属、持久性和挥发性有机物。与这些暴露相关的发育终点包括：生长受限、功能异常、结构异常、早产和死亡。尽管有这样的普遍认识，我们对大多数暴露以及导致发育受损和早产的生物相互作用的了解仍然不完整。虽然单个基因和个别化学物质暴露是造成某些不良妊娠结局或发育疾病的原因，但基因与环境的相互作用是大多数情况的原因。这些基因-环境相互作用可能发生在父亲、母亲、胎盘或胎儿中，这表明要高度重视母亲和父亲的暴露和基因表达，因为它们与怀孕前和怀孕期间假定的发育毒物的作用模式有关。
Summarize recent studies exploring the relationship between paternal and maternal environmental exposures to chemicals before, at the time of and after conception to adverse developmental outcomes including; preterm birth, death, structural and functional abnormalities and growth restriction. Recent studies have demonstrated that human pregnancy and development is vulnerable to environmental exposures of the father and mother to chemical, biological and physical agents. Exposures associated with adverse developmental outcomes include; air and water pollution, chemicals in foods, occupational exposures, agricultural chemicals, metals, persistent and volatile organics. Developmental endpoints which are linked with these exposures include; growth restriction, functional abnormalities, structural abnormalities, preterm delivery and death. Despite this general understanding we still have incomplete knowledge concerning most exposures and the biological interactions responsible for impaired development and preterm delivery. While single genes and individual chemical exposures are responsible for some instances of adverse pregnancy outcome or developmental disease, gene-environment interactions are responsible for the majority. These gene-environment interactions may occur in the father, mother, placenta or fetus suggesting that critical attention be given to maternal and paternal exposures and gene expression as they relate to the mode of action of the putative developmental toxicant both prior to and during pregnancy.