Evidence for Camel-to-Human Transmission of MERS Coronavirus
Evidence for Camel-to-Human Transmission of MERS Coronavirus
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DOI：
10.1056/nejmoa1401505
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发表时间：
2014-06-26
影响因子：
158.5
通讯作者：
Madani, Tariq A.
中科院分区：
文献类型：
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作者：
Azhar, Esam I.;El-Kafrawy, Sherif A.;Madani, Tariq A.
我们描述了中东呼吸综合征冠状病毒（MERS-CoV）的分离和测序，该冠状病毒来自单峰骆驼和一名患者，该患者在与患有腹泻的骆驼密切接触后死于实验室确认的MERS-CoV感染。从患者和他的9只骆驼中的一只收集的鼻拭子对MERS-CoV RNA呈阳性。此外，MERS-CoV从患者和骆驼中分离出来。两株分离株的全基因组序列完全相同。血清学数据表明，MERS-CoV在骆驼中传播，但在人类感染发生之前不在患者中传播。这些数据表明，这起致命的人MERS CoV感染病例是通过与受感染的骆驼密切接触传播的。
We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated from the patient and the camel. The full genome sequences of the two isolates were identical. Serologic data indicated that MERS-CoV was circulating in the camels but not in the patient before the human infection occurred. These data suggest that this fatal case of human MERS-CoV infection was transmitted through close contact with an infected camel.