COMPARISON OF SATIATING EFFECTS OF CERULETIDE AND FOOD-INTAKE USING BEHAVIORAL AND ELECTROPHYSIOLOGICAL INDICATORS OF MEMORY
COMPARISON OF SATIATING EFFECTS OF CERULETIDE AND FOOD-INTAKE USING BEHAVIORAL AND ELECTROPHYSIOLOGICAL INDICATORS OF MEMORY
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DOI：
10.1016/0167-8760(94)90058-2
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发表时间：
1994-06-01
影响因子：
3
通讯作者：
BORN, J
中科院分区：
文献类型：
--
作者：
PIETROWSKY, R;SPECHT, G;BORN, J
动物和人体研究表明，一种类似于胆囊收缩素的类似物——蓝肽具有令人满意的效果。在人类中，中枢神经对食物刺激的处理选择性减弱的迹象可能比明显的进食行为更能有效地衡量饱腹感。为了评估蓝肽对人类的满足作用，我们将蓝肽和食物摄入对食物刺激和与食物无关的刺激（中性和性别）记忆的影响与禁食受试者的记忆表现进行了比较。在实验1中，12名禁食男性在受试者内部比较中测试了对幻灯片投影单词的回忆(I)在静脉注射生理盐水溶液后，（ii）注射了ceruletide (6.75 μ g), （iii）在吃了常规早餐后。事件相关电位的P3分量被评估为记忆加工的生理标志。在实验II中，36名禁食男性在(i)给予生理盐水溶液，（II）服用6毫克的ceruletide， （iii）摄入丰盛的一餐后，以受试者间设计测试了对图片的识别。摄入食物后，对食物和性刺激的回忆和识别减弱，但对中性刺激的回忆和识别增强。蓝肽降低了对食物刺激的识别，增加了对中性刺激的识别；食物刺激和中性刺激对记忆的影响没有达到显著性。P3振幅不能反映记忆性能的变化。在进食后和进食后，对食物刺激的记忆都有所下降，说明蓝肽介导了记忆加工的满足效应。
Animal and human studies have suggested a satieting effect of ceruletide, an analog of cholecystokinin. In humans, signs of a selectively diminished central nervous processing of food stimuli may provide a more valid measure of satiety than overt eating behavior. To assess the satieting effects of ceruletide in humans, effects of ceruletide and food intake on memory of food stimuli and stimuli not related to food (neutral and sex) were compared with memory performance in fasted subjects. In experiment I, recall of slide-projected words was tested in 12 fasting men in a within-subject comparison (i) following intravenous administration of saline solution, (ii) of ceruletide (6.75 mu g), and (iii) after having eaten a regular breakfast. The P3 component of the event-related potential to the stimuli was assessed as a physiological sign of memory processing. In experiment II, recognition of pictures was tested in a between-subject design in 36 fasting men following (i) administration of saline solution, (ii) of ceruletide (6 mu g), and (iii) intake of an opulent meal. After food intake, recall and recognition of food and also of sex stimuli were diminished, but were increased for neutral stimuli. Ceruletide diminished recognition of food stimuli and increased that of neutral stimuli; similar effects on recall of food and neutral stimuli failed to reach significance. P3 amplitude did not reflect changes in memory performance. Memory of food stimuli declined after ceruletide as well as after food intake, suggesting ceruletide mediates satieting effects on memory processing.