Brainstem control of response modes in neurons of the cat's lateral geniculate nucleus.
Brainstem control of response modes in neurons of the cat's lateral geniculate nucleus.
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脑干控制猫外侧膝状核神经元的反应模式。
DOI：
10.1073/pnas.87.7.2560
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发表时间：
1990
影响因子：
11.1
通讯作者：
Sherman,SM
中科院分区：
文献类型：
--
作者：
Uhlrich,DJ;Tamamaki,N;Sherman,SM
猫从视网膜通过外侧膝状核到视皮层的视觉通路由几个平行的神经元流组成，它们独立地分析视觉场景的不同方面。其中最著名的是通过膝状A板层传递的X和Y通路。最近对视网膜和膝状核神经元的感受野研究表明，在外侧膝状核水平上有进一步的细胞类型的阐述。也就是说，两种类型的膝状X细胞对视觉刺激的反应具有不同的时间模式，一种具有“非滞后”特征，表现出较短的反应潜伏期，另一种具有“滞后”特征；所有的视网膜X细胞都是非滞后的。我们询问非滞后反应和滞后反应是否代表不同的细胞类别或同一细胞的两种反应模式，可能受这些中继细胞的非视网膜传入的控制。因此，我们研究了电激活中脑臂旁区域对适当感受野特性的影响，臂旁区域是中继细胞的主要非视网膜输入。这种臂旁刺激使8个滞后的X细胞中的每一个都更像非滞后细胞，这种刺激完全将8个细胞中的6个细胞的滞后反应曲线转变为非滞后细胞。因此，我们得出结论，延迟性反应是外侧膝状体的一种突现特性，是同一细胞的一种不同的反应模式，也可以表现出非滞后反应，而不是代表不同的细胞类别；此外，这种反应模式之间的切换，至少部分地受到臂旁区域传入神经的控制。
The visual pathway from retina through the lateral geniculate nucleus to visual cortex in the cat is comprised of several parallel neuronal streams that independently analyze different aspects of the visual scene. The best known of these are the X and Y pathways that relay through the geniculate A laminae. Recent receptive-field studies of retinal and geniculate neurons suggest that there is a further elaboration of cell types at the level of the lateral geniculate nucleus. That is, two types of geniculate X cells with different temporal patterns of responses to visual stimuli are recognized, one with "nonlagged" features, exhibiting shorter response latencies and another with "lagged" features; all retinal X cells are nonlagged. We asked whether nonlagged and lagged responses represent different cell classes or two response modes of the same cells, perhaps under the control of nonretinal afferents to these relay cells. Accordingly, we studied the effects on appropriate receptive-field properties of electrical activation of the midbrain parabrachial region, which is a major nonretinal input to relay cells. Such parabrachial stimulation made each of the eight lagged X cells much more like nonlagged cells, and this stimulation completely transformed the lagged response profiles of six of the eight cells to nonlagged. We thus conclude that the property of lagged responsiveness, which is an emergent property of the lateral geniculate nucleus, is a different response mode of the same cells that can also display nonlagged responses, rather than representing different cell classes; furthermore, this switching between response modes is, at least partly, under the control of afferents from the parabrachial region.