Sodium regulation of alpha 2-adrenoreceptors of human platelets: inactivation by 4,4'-diisothiocyano-2,2'-stilbene disulfonic acid (DIDS).
Sodium regulation of alpha 2-adrenoreceptors of human platelets: inactivation by 4,4'-diisothiocyano-2,2'-stilbene disulfonic acid (DIDS).
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人血小板α2-肾上腺素受体的钠调节：4,4-二异硫氰基-2,2-二苯乙烯二磺酸 (DIDS) 失活。
DOI：
10.1016/s0006-291x(86)80357-6
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发表时间：
1986
影响因子：
3.1
通讯作者：
Somani,P
中科院分区：
文献类型：
--
作者：
Periyasamy,SM;Somani,P
In the present study, we investigated the effect of DIDS on Na+regulation of α2-adrenoreceptors in human platelets. Pretreatment of platelet membranes at 23°C for 60 min with DIDS produced a reduction in the affinity of the receptors for both antagonist and agonist in a concentration related manner; however, there was a marked difference in the degree of reduction in the affinity of the receptors for antagonist and agonist. Thus, at 1 mM concentration of DIDS, the affinity of the receptors for antagonist was reduced by 2-fold while the affinity of the receptors for agonist was reduced by 14-fold. Furthermore, this concentration of DIDS abolished the ability of Na+in reducing the affinity of the receptors for agonist. We suggest that the effect of DIDS is via Na+binding component of the α2-adrenoreceptor-adenylate cyclase complex.
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