Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa
Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa
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DOI：
10.1038/sj.eye.6703076
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发表时间：
2009-02-01
期刊：
影响因子：
3.9
通讯作者：
Yamamoto, S.
中科院分区：
文献类型：
--
作者：
Aizawa, S.;Mitamura, Y.;Yamamoto, S.
目的探讨视网膜色素变性(RP)患者的视力、中心凹厚度与光感受器内外节段连接(IS/OS)状态是否存在显著相关性。方法对163例300只眼进行光学相干断层扫描(OCT)检查。在Oct3图像中，IS/OS显示为一条清晰的、高反射线，恰好是视网膜色素上皮的玻璃体。IS/OS系列被分成三组。结果1级未见IS/OS线93眼(31.0%)，2级IS/OS异常67眼(22.3%)，3级IS/OS正常140眼(46.7%)。IS/OS分级与年龄无显著相关性(P=0.5536)。IS/OS分级与BCVA、CFT呈显著正相关(P
Purpose To determine whether a significant correlation exists between the visual acuity or foveal thickness and the status of the inner and outer segment junction (IS/OS) of the photoreceptor in patients with retinitis pigmentosa (RP).Methods Three hundred eyes of 163 patients with RP were examined with the optical coherence tomography (OCT). The IS/OS appeared as a distinct, highly reflective line just vitread of the retinal pigment epithelium in the OCT3 images. The IS/OS line was graded into three groups. The correlations between the grade of the IS/OS and age, best-corrected visual acuity (BCVA), and central foveal thickness (CFT) were determined.Results Grade 1 included 93 eyes (31.0%) in which an IS/OS line was not seen, Grade 2 included 67 eyes (22.3%) with an abnormal IS/OS, and Grade 3 included 140 eyes (46.7%) with a normal IS/OS. The correlation between the IS/OS grade and age was not significant (P = 0.5536). The IS/OS grade was significantly correlated with BCVA and CFT (both P