Dosage compensation and chromatin structure in Drosophila
Dosage compensation and chromatin structure in Drosophila
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DOI：
10.1016/s0959-437x(96)80073-6
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发表时间：
1996-08-01
影响因子：
4
通讯作者：
Baker, BS
中科院分区：
文献类型：
--
作者：
Bashaw, GJ;Baker, BS
在过去的一年里，我们对果蝇雄性特异性致死（msl）基因和剂量补偿的理解取得了重大进展。msl-2基因的分子特征在很大程度上解决了msl介导的剂量补偿如何仅限于雄性的问题。对msl基因的分子分析证实了MSL蛋白作为多聚体复合物介导剂量补偿的建议。MSL-2蛋白具有RING指的发现和绝缘子蛋白促进插入常染色体的X连锁基因的剂量补偿的证明为识别顺式作用剂量补偿决定簇开辟了有希望的途径。
The past year has brought significant advances in our understanding of the male-specific lethal (msl) genes and dosage compensation in Drosophila. The molecular characterization of the msl-2 gene has, to a great extent, solved the question of how msl-mediated dosage compensation is restricted to males. Molecular analyses of the msl genes have substantiated the proposal that the MSL proteins function as a multimeric complex to mediate dosage compensation. The finding that MSL-2 protein has a RING finger and the demonstration that an insulator protein facilitates the dosage compensation of X-linked genes inserted into the autosomes have opened promising avenues to identify the cis-acting dosage-compensation determinants.