Impaired associative inference in the early stage of psychosis
Impaired associative inference in the early stage of psychosis
复制标题
DOI：
10.1016/j.schres.2018.06.049
复制
发表时间：
2018-12-01
影响因子：
4.5
通讯作者：
Heckers, Stephan
中科院分区：
文献类型：
--
作者：
Armstrong, Kristan;Avery, Suzanne;Heckers, Stephan
关系记忆在慢性精神分裂症中受损。目前尚不清楚在精神病的早期阶段是否已经存在类似的缺陷。我们使用联想推理范式来测试非情感性精神病早期阶段的关系记忆能力。对82例早期精神病患者和67例健康对照进行3组30对联想训练：H-F1（房子与面孔配对）、H-F2（同一房子与新面孔配对）、F3-F4（两张新面孔）。在训练中，对配对的记忆准确度达到80%的受试者，然后测试他们回忆以前见过的配对的能力，并解决一个新的推断配对F1-F2（通过联想到同一所房子而联系起来的面孔）。60例早期精神病患者（73%）和67例健康对照者（100%）在训练中成功达到准确率阈值（80%），被纳入关系记忆分析。早期精神病患者的关联推断效应低于健康对照组(组间相互作用的配对型：F (1,125) = 5.04, p
Relational memory is impaired in chronic schizophrenia. It is unclear if similar deficits are already present in the early stage of psychosis. We used the Associative Inference Paradigm to test relational memory ability in the early stage of a non-affective psychotic disorder. Eighty-two early stage psychosis patients and 67 healthy control subjects were trained on 3 sets of 30 paired associates: H-F1 ( house paired with face), H-F2 (same house paired with new face), F3-F4 (two new faces). Subjects who reached 80% recall accuracy of the paired associates during training were then tested for their ability to recall the previously seen pairs and solve a novel, inferential pairing F1-F2 (faces linked through association to same house). Sixty early psychosis patients (73%) and 67 healthy control subjects (100%) successfully reached the accuracy threshold (80%) during training and were included in the analysis of relational memory. The early stage psychosis patients showed less of an associative inference effect than the healthy controls (pair type by group interaction: F (1,125) = 5.04, p