BEHAVIORAL AND PSYCHIATRIC-DISORDERS IN ADULT MALE CARRIERS OF FRAGILE-X
BEHAVIORAL AND PSYCHIATRIC-DISORDERS IN ADULT MALE CARRIERS OF FRAGILE-X
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DOI：
10.1097/00004583-199402000-00015
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发表时间：
1994-02-01
影响因子：
13.3
通讯作者：
HAGERMAN, RJ
中科院分区：
文献类型：
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作者：
DORN, MB;MAZZOCCO, MMM;HAGERMAN, RJ
目的：在本研究中，我们调查了脆性X基因男性携带者的精神和行为问题的发生率。方法：采用家庭告密者法收集男性携带者的回顾性资料。一位对父亲身份视而不见的检查员对56名脆弱的X携带者妇女进行了关于她父亲的面谈。面试者测量了(1)与DSM-III-R轴I障碍有关的行为，(2)成人注意缺陷多动障碍(ADHD)行为，(3)父母关系技巧，(4)虐待行为。将24名患有脆性X染色体的女性的背书与32名患有非脆性X染色体的女性的背书进行了比较。结果：结果显示，脆性X男性(相对于非脆性X父亲)与成人ADHD、父母关系、虐待有关的行为，特别是酒精滥用/依赖和强迫症行为的精神病理学发生率更高。结论：这些发现支持这样的假设，即一些“非穿透性”男性可能确实是轻度影响的携带者，并且在携带者男性中存在广泛的参与。
Objective: In the present study we examined the incidence of psychiatric and behavioral problems among male carriers of the fragile X gene. Method: Retrospective data on carrier males were gathered using the family informant method. Each of 56 fragile X carrier women was interviewed about her father by an examiner blind to the father's carrier status. The interviewer administered measures of (1) behaviors related to DSM-III-R Axis I disorders, (2) adult attention-deficit hyperactivity disorder (ADHD) behaviors, (3) parental bonding skills, and (4) abusive behaviors. The endorsements from 24 women with fragile X fathers were compared with endorsements from 32 women with nonfragile X fathers. Results: The results show a higher incidence of psychopathology among the fragile X males (relative to nonfragile X fathers) for behaviors related to adult ADHD, parental bonding, abuse; and particularly for alcohol abuse/dependence and obsessive-compulsive disorder behaviors. Conclusions: These findings support the hypotheses that some ''nonpenetrant'' males may indeed be mildly affected carriers and that there is a broad spectrum of involvement among carrier males.