Progression and predictors of mild cognitive impairment in Chinese elderly: A prospective follow-up in the Shanghai Aging Study.
Progression and predictors of mild cognitive impairment in Chinese elderly: A prospective follow-up in the Shanghai Aging Study.
复制标题
中国老年人的轻度认知障碍的进展和预测指标：上海衰老研究的前瞻性随访。
DOI：
10.1016/j.dadm.2016.03.004
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Shanghai Aging Study (SAS)
中科院分区：
文献类型：
--
作者：
Ding D;Zhao Q;Guo Q;Liang X;Luo J;Yu L;Zheng L;Hong Z;Shanghai Aging Study (SAS)
上海老龄化研究是一项以社区为基础的研究，旨在调查中国老年人认知能力下降的发生率和进展情况，其操作程序和诊断标准与发达国家的队列研究类似。我们前瞻性地评估了 362 名在基线时通过临床和神经心理学访谈诊断出患有轻度认知障碍 (MCI) 的个体。痴呆症和 MCI 的诊断是使用标准标准通过共识诊断进行的。痴呆症的转化率为每 100 人年 6.0 人，而认知正常的恢复率为每 100 人年 7.8 人。遗忘性 MCI 多领域是痴呆风险最高的类型（转化率：每 100 人年 14.2 人）。年龄较大（风险比 [HR] = 1.09）、载脂蛋白 E (APOE ε4) (HR = 2.15) 和低 MMSE 评分 (HR = 1.18) 是痴呆症的预测因素。每年大约 6% 患有 MCI 的老年人发展为痴呆。需要进行前瞻性研究来进一步检查风险和保护性预测因素，并寻求针对认知能力下降的适当干预措施。
The Shanghai Aging Study is a community-based study aiming to investigate the incidence and progression of cognitive decline in Chinese elderly, with the operational procedures and diagnostic criteria similar to cohort studies in developed countries. We prospectively evaluated 362 individuals with mild cognitive impairment (MCI) diagnosed at baseline through a clinical and neuropsychological interview. Diagnoses of dementia and MCI were made using standard criteria via consensus diagnosis. The conversion rate to dementia was 6.0 per 100 person-years, while the reversion rate to cognitive normal was 7.8 per 100 person-years. Amnestic MCI multiple domains was the most risky type for dementia (conversion rate: 14.2 per 100 person-years). Older age (hazard ratio [HR] = 1.09), apolipoprotein E (APOE ε4) (HR = 2.15), and low MMSE score (HR = 1.18) were predictors for dementia. Approximately 6% of elderly with MCI progress to dementia annually. Prospective studies are needed to further examine risk and protective predictors and to seek proper interventions for cognitive decline.