Mutation and inactivation of mammalian cells by various ionising radiations
Mutation and inactivation of mammalian cells by various ionising radiations
复制标题
各种电离辐射导致哺乳动物细胞突变和失活
作者：
R. Cox;J. Thacker;D. Goodhead;R. J. Munson
几乎没有关于各种电离辐射对人类的诱变效果的信息，只有有限的关于实验哺乳动物的X或γ射线以外的辐射的信息。我们测量了在各种辐射下培养的哺乳动物细胞的失活和突变诱导，辐射覆盖了一系列线性能量转移(LET；参考文献。1)。我们证明了对于两种细胞类型，这些辐射的最大诱变效率，相对于X射线或γ射线，大约是灭活的两倍。初步实验表明，特定的染色体异常可能与高LET辐射诱导的突变有关。
THERE is almost no information on the mutagenic effectiveness of the various ionising radiations for man and only limited information about radiations other than X or γ rays for experimental mammals. We have measured inactivation and mutation induction in cultured mammalian cells exposed to various radiations covering a range of linear energy transfer (LET; ref. 1). We show for two cell types that the maximum mutagenic effectiveness of these radiations, relative to X or γ rays, is about twice that for inactivation. Preliminary experiments suggest that specific chromosome aberrations may be associated with mutations induced by radiations of high LET.