Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta
Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta
复制标题
DOI：
10.1016/s0021-9290(03)00088-5
复制
发表时间：
2003-08-01
影响因子：
2.4
通讯作者：
Truskey, GA
中科院分区：
文献类型：
--
作者：
Buchanan, JR;Kleinstreuer, C;Truskey, GA
采用兔腹主动脉作为合适的动脉粥样硬化模型，采用瞬时三维血流模拟和单核细胞沉积模式来评估以下假设：(I)模拟单核细胞通过兔腹主动脉的传输产生与体内所见相似的细胞沉积模式，以及(Ii)这些沉积模式与动脉粥样硬化相关的血流动力学壁参数相关。随着血管分支周围单核细胞黏附的局部升高，沉积模式沿着主动脉呈螺旋状。运动波形改变了细胞的沉积模式，较少的细胞附着在腹主动脉上，而更多的细胞附着在肾口周围。单核细胞沉积与壁面切应力梯度和壁面切应力角度梯度相关。壁应力梯度、壁切应力角度梯度和归一化单核细胞沉积分数与单核细胞在腹主动脉的分布相关，单核细胞沉积与单核细胞在腹主动脉主要分支周围的实测值相关。这些结果表明单核细胞向动脉内皮细胞的运输和沉积模式在病变的定位中起着重要作用。(C)2003爱思唯尔科学有限公司。保留所有权利。
Employing the rabbit's abdominal aorta as a suitable atherosclerotic model, transient three-dimensional blood flow simulations and monocyte deposition patterns were used to evaluate the following hypotheses: (i) simulation of monocyte transport through a model of the rabbit abdominal aorta yields cell deposition patterns similar to those seen in vivo, and (ii) those deposition patterns are correlated with hemodynamic wall parameters related to atherosclerosis. The deposition pattern traces a helical shape down the aorta with local elevation in monocyte adhesion around vessel branches. The cell deposition pattern was altered by an exercise waveform with fewer cells attaching in the upper abdominal aorta but more attaching around the renal orifices. Monocyte deposition was correlated with the wall shear stress gradient and the wall shear stress angle gradient. The wall stress gradient, the wall shear stress angle gradient and the normalized monocyte deposition fraction were correlated with the distribution of monocytes along the abdominal aorta and monocyte deposition is correlated with the measured distribution of monocytes around the major abdominal branches in the cholesterol-fed rabbit. These results suggest that the transport and deposition pattern of monocytes to arterial endothelium plays a significant role in the localization of lesions. (C) 2003 Elsevier Science Ltd. All rights reserved.