Ritanserin, a serotonin-2 receptor antagonist, improves ultradian sleep rhythmicity in young poor sleepers
Ritanserin, a serotonin-2 receptor antagonist, improves ultradian sleep rhythmicity in young poor sleepers
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DOI：
10.1016/s1388-2457(02)00014-7
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发表时间：
2002-03
影响因子：
4.7
通讯作者：
A. Viola;G. Brandenberger;M. Toussaint;P. Bouhours;J. Macher;R. Luthringer
中科院分区：
文献类型：
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作者：
A. Viola;G. Brandenberger;M. Toussaint;P. Bouhours;J. Macher;R. Luthringer
ObjectivesTo determine the effects on sleep electroencephalographic（EEG）activity of ritanserin，a serotonin-2（5-HT 2）receptor antagonist in young poor sleepers.MethodsEight men subjects undergoing two randomized night studies after receiving either a placebo or 5mg ritanserin administered in the morning.结果利坦色林组慢波睡眠时间和非快速眼动（NREM）-快速眼动（REM）睡眠周期数明显增加（P<0.01），而对照组无显著性差异（P> 0.05）。在正常80- 120 min范围内出现的δ活性峰数明显增多（P<0.05）。使用δ峰分析，在每例受试者中确定了4个包含或不包含显著峰的时间段。在第二和第三周期，δ活性在平均曲线下面积显著增加（P<0.05），而在第一、第二和第三周期，在利坦色林作用下δ活性降低（P<0.05）。它恢复睡眠超日节律，改善睡眠质量的年轻人。
ObjectivesTo determine the effect on sleep electroencephalographic (EEG) activity of ritanserin, a serotonin-2 (5-HT2) receptor antagonist in young poor sleepers.MethodsEight male subjects underwent two randomized night studies after receiving either a placebo or 5mg ritanserin administered in the morning. The overnight variations in the delta (0.5–4.0Hz) and sigma (12.25–15.0Hz) frequency bands were characterized using a peak analysis which provided a quantitative evaluation of the time-courses in EEG activity.ResultsIn subjects under ritanserin, slow wave sleep duration and the number of non-rapid eye movement (NREM)–REM sleep cycles were significantly enhanced (P<0.01). The number of peaks in delta activity occurring in the normal 80–120min range was significantly (P<0.05) increased. Using a delta peak analysis, 4 periods containing or not a significant peak were identified in each subject. A significant increase in delta activity was observed in the areas under the averaged curves during the second and the third periods (P<0.05), while sigma activity decreased under ritanserin during the first, second and third periods (P<0.05).ConclusionsThese results demonstrate that ritanserin increases delta activity, possibly by opposing the inhibitory control of 5-HT2receptor family. It restores sleep ultradian rhythmicity and improves sleep quality in young poor sleepers.