Persistence of circadian variation in arterial blood pressure in β1/β2-adrenergic receptor-deficient mice
Persistence of circadian variation in arterial blood pressure in β1/β2-adrenergic receptor-deficient mice
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DOI：
10.1152/ajpregu.00074.2008
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发表时间：
2008-05-01
影响因子：
2.8
通讯作者：
Briggs, Josephine P.
中科院分区：
文献类型：
--
作者：
Kim, Soo Mi;Huang, Yuning;Briggs, Josephine P.
β 1/ β 2肾上腺素能受体缺乏小鼠动脉血压昼夜变化的持久性[J] .中国生物医学工程学报，2016,33(4):557 - 557。首次发表于2008年2月27日；doi: 10.1152 / ajpregu.00074.2008。-肾上腺素能通路被认为是动脉压昼夜变化的一个重要影响因素。在β 1/ β 2-肾上腺素能受体缺乏的小鼠（β 1/ β 2ADR -/-）中进行了实验，以评估该通路是否与平均动脉压（MAP）的昼夜变化有关，并确定其缺失对饮食盐变化的反应的影响。对有意识的16 ~ 17周龄小鼠进行24小时MAP、心率（HR）和运动活动的记录[野生型，（WT）， n = 7；β 1/ β 2ADR -/-, n = 10]。WT和β 1/ β 2ADR -/-小鼠的MAP和HR均表现出强烈的昼夜变化，尽管β 1/ β 2ADR -/-小鼠的24小时平均MAP比WT低10%(102.02 +/- 1.81比92.11 +/- 2.62 mmHg)， HR低16%，昼夜差异减小。WT和β 1/ β 2ADR -/-小鼠均适应盐摄入量的改变，但MAP没有改变。然而，β 1/ β 2ADR -/-小鼠在白天的光明和黑暗阶段表现出显著的运动活动减少。在WT小鼠中，MAP明显受到运动活动的影响，导致光照和黑暗条件下的双峰分布。当仅使用无运动活动的时间间隔分析MAP时，双峰性和昼夜节律差异减少，两种基因型之间无显著差异。结果表明，除了运动活动改变的间接后果外，β -肾上腺素能系统在小鼠动脉压的昼夜变化中没有直接影响或作用。我们的研究结果还证实，运动活动对小鼠血压的昼夜变化有很大影响。
Persistence of circadian variation in arterial blood pressure in beta 1/ beta 2-adrenergic receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol 294: R1427-R1434, 2008. First published February 27, 2008; doi:10.1152/ajpregu.00074.2008.-The beta-adrenergic pathway has been considered one important effector of circadian variation in arterial pressure. Experiments were performed in beta 1/ beta 2-adrenergic receptor-deficient mice ( beta 1/ beta 2ADR -/-) to assess whether this pathway is required for circadian variation in mean arterial pressure ( MAP) and to determine the impact of its loss on the response to changes in dietary salt. Twenty-four-hour recordings of MAP, heart rate ( HR), and locomotor activity were made in conscious 16- to 17-wk-old mice [ wild-type, ( WT), n = 7; beta 1/ beta 2ADR -/-, n = 10] by telemetry. Both WT and beta 1/ beta 2ADR -/- mice demonstrated robust circadian variation in MAP and HR, although 24-h mean MAP was 10% lower ( 102.02 +/- 1.81 vs. 92.11 +/- 2.62 mmHg) in beta 1/ beta 2ADR -/- than WT, HR was 16% lower and day-night differences reduced. Both WT and beta 1/ beta 2ADR -/- mice adapted to changed salt intake without changed MAP. However, the beta 1/ beta 2ADR -/- mice demonstrated a striking reduction in locomotor activity in light and dark phases of the day. In WT mice, MAP was markedly affected by locomotor activity, resulting in bimodal distributions in both light and dark. When MAP was analyzed using only intervals without locomotor activity, bimodality and circadian differences were reduced, and there was no significant difference between the two genotypes. The results indicate that there is no direct effect or role for the beta-adrenergic system in circadian variation of arterial pressure in mice, aside from the indirect consequences of altered locomotor activity. Our results also confirm that locomotor activity contributes strongly to circadian variation in blood pressure in mice.