Effect of a nonspiking neuron on motor patterns of the leech.
Effect of a nonspiking neuron on motor patterns of the leech.
复制标题
非尖峰神经元对水蛭运动模式的影响。
DOI：
10.1152/jn.01070.2011
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发表时间：
2012
影响因子：
2.5
通讯作者：
L. Szczupak
中科院分区：
文献类型：
--
作者：
M. J. Rodriguez;Rodrigo J. Alvarez;L. Szczupak
运动前神经元和运动神经元可能在运动控制中起调节作用。我们研究了水蛭神经系统的运动前非尖峰（NS）神经元在游泳和爬行两种运动模式中的作用。NS神经元通过整流电连接连接到所有被检查的兴奋性运动神经元。此外，运动神经元的激活引起NS中化学介导的抑制反应。在游泳和爬行过程中，NS膜电位（Vm(NS)）振荡锁相于电机输出。NS的超极化和去极化对游泳无影响，但NS的超极化使爬行活动减慢，运动神经元放电频率降低。NS去极化使运动神经元活动增加，并且在爬行模式消退的阶段，NS去极化使其恢复。未来的工作应该确定NS实际上是中央模式发生器的成员还是一个调节元素。
Premotor and motoneurons could play regulatory roles in motor control. We have investigated the role of a premotor nonspiking (NS) neuron of the leech nervous system in two locomotive patterns: swimming and crawling. The NS neuron is coupled through rectifying electrical junctions to all the excitatory motoneurons examined. In addition, activation of motoneurons evokes chemically mediated inhibitory responses in NS. During swimming and crawling, the NS membrane potential (Vm(NS)) oscillated phase locked to the motor output. Hyperpolarization or depolarization of NS had no effect on swimming, but hyperpolarization of NS slowed down the crawling activity and decreased the motoneuron firing frequency. Depolarization of NS increased the motoneuron activity, and, at stages where the crawling pattern was fading, depolarization of NS reinstated it. Future work should determine if NS is actually a member of the central pattern generator or a regulatory element.