LPCing through the nephron accelerates diabetic kidney disease.
LPCing through the nephron accelerates diabetic kidney disease.
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DOI：
10.1016/j.kint.2021.12.013
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发表时间：
2022-03
影响因子：
19.6
通讯作者：
J. Pressly;M. Ge;A. Fornoni
中科院分区：
文献类型：
--
作者：
J. Pressly;M. Ge;A. Fornoni
脂类代谢异常是糖尿病肾病的重要因素，提示肾内脂类积聚对肾功能有害。这篇评论讨论了Yoshiokaet等人的发现，即在糖尿病肾病快速发展的患者中，由局部产生的溶血磷脂酰胆碱增加而引起的小管脂肪毒性，被称为“快速下降”。深入了解肾脏中的脂质种类可能有助于糖尿病肾病患者的诊断和分层。
Lipid dysmetabolism is emerging as an important contributor to diabetic kidney disease, suggesting that intrarenal lipid accumulation is detrimental to kidney function. This commentary discusses the finding by Yoshiokaet al., connecting tubular lipotoxicity induced by an increase in locally produced lysophosphatidylcholine in patients with a fast progression of diabetic kidney disease, known as “fast decliner.” Insight into the lipid species in the kidney may prove beneficial for the diagnosis and stratification of patients with diabetic kidney disease.