Multiplexed NMR: an automated CapNMR dual-sample probe.
Multiplexed NMR: an automated CapNMR dual-sample probe.
复制标题
多重 NMR：自动化 CapNMR 双样品探针。
DOI：
10.1021/ac101003f
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发表时间：
2010
影响因子：
7.4
通讯作者：
Peck,TimothyL
中科院分区：
文献类型：
--
作者：
Norcross,JamesA;Milling,CraigT;Olson,DeanL;Xu,Duanxiang;Audrieth,Anthony;Albrecht,Robert;Ruan,Ke;Likos,John;Jones,Claude;Peck,TimothyL
新一代的微型核磁共振（CapNMR）探针技术采用两个独立的检测元件，可同时容纳两个样品。双样品CapNMR探头（DSP）中的每个检测元件提供与配置为一次容纳一个样品的CapNMR探头相同的光谱分辨率和S/N。高度的电气隔离使DSP能够用于各种数据采集模式。两个样品同时被匀场以实现用于同时数据采集的高光谱分辨率，或者可替代地，通过光谱仪子例程容易地调用流动池特定的匀场组以使得能够在加载另一个样品的同时从一个样品采集。自动化系统可通过自动进样器上的双进样口和两个完全独立的流路加载两个样品，流路通向DSP探头中的专用流通池。
A new generation of microscale, nuclear magnetic resonance (CapNMR) probe technology employs two independent detection elements to accommodate two samples simultaneously. Each detection element in the dual-sample CapNMR probe (DSP) delivers the same spectral resolution and S/N as in a CapNMR probe configured to accommodate one sample at a time. A high degree of electrical isolation allows the DSP to be used in a variety of data acquisition modes. Both samples are shimmed simultaneously to achieve high spectral resolution for simultaneous data acquisition, or alternatively, a flowcell-specific shim set is readily called via spectrometer subroutines to enable acquisition from one sample while the other is being loaded. An automation system accommodates loading of two samples via dual injection ports on an autosampler and two completely independent flowpaths leading to dedicated flowcells in the DSP probe.