Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance.
Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance.
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DOI：
10.7554/elife.59281
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发表时间：
2020-10-15
期刊：
影响因子：
7.7
通讯作者：
Quirk GJ
中科院分区：
文献类型：
--
作者：
Diehl MM;Iravedra-Garcia JM;Morán-Sierra J;Rojas-Bowe G;Gonzalez-Diaz FN;Valentín-Valentín VP;Quirk GJ
前额叶皮层（PFC）整合传入的信息来指导我们的行动。当寻找食物的动机与避免危险的动机竞争时，前额叶皮层可能在选择最佳选择方面发挥作用。在平台介导的主动回避中，大鼠通过踩到附近的平台来避免音调信号的足震，从而延迟获得蔗糖颗粒。这种回避需要前边缘（PL）PFC，基底外侧杏仁核（BLA）和腹侧纹状体（VS）。我们先前表明PL神经元的抑制性紧张性反应与休克的可避免性相关（Diehl等人，2018年）。在这里，我们光遗传学调制PL终端VS和BLA，以确定PL输出调节回避。光活化PL-VS预测减少回避，而光活化PL-BLA预测增加回避。此外，光沉默PL-BLA或BLA-VS预测减少回避，表明VS接收来自PL和BLA的相反输入。通过PL投射到VS和BLA的双向回避调制使动物在面对竞争驱动时能够做出适当的决定。
The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance of danger, the PFC likely plays a role in selecting the optimal choice. In platform-mediated active avoidance, rats avoid a tone-signaled footshock by stepping onto a nearby platform, delaying access to sucrose pellets. This avoidance requires prelimbic (PL) PFC, basolateral amygdala (BLA), and ventral striatum (VS). We previously showed that inhibitory tone responses of PL neurons correlate with avoidability of shock (Diehl et al., 2018). Here, we optogenetically modulated PL terminals in VS and BLA to identify PL outputs regulating avoidance. Photoactivating PL-VS projections reduced avoidance, whereas photoactivating PL-BLA projections increased avoidance. Moreover, photosilencing PL-BLA or BLA-VS projections reduced avoidance, suggesting that VS receives opposing inputs from PL and BLA. Bidirectional modulation of avoidance by PL projections to VS and BLA enables the animal to make appropriate decisions when faced with competing drives.