Long-term vonoprazan administration causes gastric fundic gland-type hyperplastic polyps and chronic bleeding
Long-term vonoprazan administration causes gastric fundic gland-type hyperplastic polyps and chronic bleeding
复制标题
长期服用沃诺拉赞导致胃底腺型增生性息肉和慢性出血
DOI：
10.1007/s12328-022-01751-0
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发表时间：
2022
影响因子：
1
通讯作者：
Kato Naoya
中科院分区：
文献类型：
--
作者：
Goto Chihiro;Okimoto Kenichiro;Matsusaka Keisuke;Matsumura Tomoaki;Akizue Naoki;Ohta Yuki;Taida Takashi;Saito Keiko;Kato Jun;Kato Naoya
1例胃底腺型增生性息肉，由小凹上皮和壁细胞组成，长期应用伏诺哌嗪治疗后并发慢性出血。病人有进行性贫血，可能是由息肉出血引起的。从伏诺哌嗪转为组胺-2 （H2）受体拮抗剂后，息肉明显缩小，贫血得到改善。Vonoprazan可引起可逆性增生性息肉和贫血。对于长期服用伏诺哌嗪的贫血患者，考虑停药或改用H2阻滞剂是很重要的。
A patient experienced gastric fundic gland-type hyperplastic polyps, consisting of foveolar epithelium and parietal cells, complicated with chronic bleeding due to long-term treatment with vonoprazan. The patient had progressive anemia, probably caused by bleeding from the polyps. After switching from vonoprazan to a histamine-2 (H2) receptor antagonist, the polyps markedly shrank and the anemia improved. Vonoprazan can produce reversible hyperplastic polyps and anemia. In case of anemia in patients receiving long-term vonoprazan, it is important to consider drug cessation or change to an H2 blocker.