Outcomes of CSF shunting in children: comparison of Hydrocephalus Clinical Research Network cohort with historical controls
Outcomes of CSF shunting in children: comparison of Hydrocephalus Clinical Research Network cohort with historical controls
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DOI：
10.3171/2013.7.peds12637
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发表时间：
2013-10-01
影响因子：
1.9
通讯作者：
Whitehead, William E.
中科院分区：
文献类型：
--
作者：
Kulkarni, Abhaya V.;Riva-Cambrin, Jay;Whitehead, William E.
对象。脑积水临床研究网络（HCRN）由北美7个儿科神经外科中心组成，为非选择性患者脑脊液分流的当前结果提供了独特的多中心评估。作者介绍了该队列的初步结果，并将其与20世纪90年代进行的前瞻性多中心试验的结果进行了比较。分析仅限于首次接受分流术的新诊断脑积水患者。所有HCRN中心2008年至2012年的详细围手术期数据由训练有素的研究协调员前瞻性地收集和集中存储。历史对照数据来自分流器设计试验（1993-1995）和内镜分流器插入试验（1996-1999）。主要终点是首次分流失败的时间，通过Cox回归生存分析确定。HCRN队列中1184例患者的平均年龄比历史队列中720例患者的平均年龄大(2.51岁vs 1.60岁，p
Object. The Hydrocephalus Clinical Research Network (HCRN), which comprises 7 pediatric neurosurgical centers in North America, provides a unique multicenter assessment of the current outcomes of CSF shunting in nonselected patients. The authors present the initial results for this cohort and compare them with results from prospective multicenter trials performed in the 1990s.Methods. Analysis was restricted to patients with newly diagnosed hydrocephalus undergoing shunting for the first time. Detailed perioperative data from 2008 through 2012 for all HCRN centers were prospectively collected and centrally stored by trained research coordinators. Historical control data were obtained from the Shunt Design Trial (1993-1995) and the Endoscopic Shunt Insertion Trial (1996-1999). The primary outcome was time to first shunt failure, which was determined by using Cox regression survival analysis.Results. Mean age of the 1184 patients in the HCRN cohort was older than mean age of the 720 patients in the historical cohort (2.51 years vs 1.60 years, p