Grafting poly(ethylene glycol) monomethacrylate onto Fe3O4 nanoparticles to resist nonspecific protein adsorption
Grafting poly(ethylene glycol) monomethacrylate onto Fe3O4 nanoparticles to resist nonspecific protein adsorption
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DOI：
10.1016/j.apsusc.2010.07.050
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发表时间：
2010-11
影响因子：
6.7
通讯作者：
Shaoxiong Qin;Linlin Wang;Xu Zhang;Gaoshen Su
中科院分区：
文献类型：
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作者：
Shaoxiong Qin;Linlin Wang;Xu Zhang;Gaoshen Su
采用可逆加成-断裂链转移（RAFT）聚合法制备了聚乙二醇单甲基丙烯酸酯（P（PEGMA））接枝磁性纳米粒子。该方法首先将S-苄基S′-三甲氧基硅丙基三硫代碳酸酯作为RAFT的链转移剂固定在磁性纳米粒子表面，然后通过RAFT聚合将PEGMA接枝到磁性纳米粒子表面。结果表明，P（PEGMA）链是通过表面诱导RAFT聚合从磁性纳米粒子上长出的。接枝的P（PEGMA）链可以降低蛋白质在Fe 3 O 4纳米粒子表面的非特异性吸附。
Magnetic nanoparticles grafted with poly(poly(ethylene glycol) monomethacrylate) (P(PEGMA)) were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. In this approach, S-benzyl S′-trimethoxysilylpropyltrithiocarbonate, used as a chain transfer agent for RAFT, was first immobilized onto the magnetic nanoparticle surface, and then PEGMA was grafted onto the surface of magnetic nanoparticle via RAFT polymerization. The results showed that P(PEGMA) chains grew from magnetic nanoparticles by surface-induced RAFT polymerization. The grafted P(PEGMA) chains can decrease the nonspecific adsorption of proteins on the surface of Fe3O4nanoparticles.