The glucocorticoid analog dexamethasone alters the expression and the distribution of dopamine receptors and enkephalin within cortico-subcortical regions.
The glucocorticoid analog dexamethasone alters the expression and the distribution of dopamine receptors and enkephalin within cortico-subcortical regions.
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糖皮质激素类似物地塞米松改变皮质-皮质下区域内多巴胺受体和脑啡肽的表达和分布。
DOI：
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发表时间：
2013
影响因子：
2.7
通讯作者：
A. de Bartolomeis
中科院分区：
文献类型：
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作者：
F. Iasevoli;L. Aloj;G. Latte;L. Avvisati;F. Marmo;C. Tomasetti;E. Buonaguro;C. Simeoli;R. Pivonello;A. Colao;A. de Bartolomeis
在人类中，糖皮质激素过量可能导致神经精神症状，包括精神病和认知障碍，糖皮质激素信号过度激活可能会使人对滥用物质敏感。这项工作的目的是评估暴露于糖皮质激素过量是否会触发相关前脑区域内多巴胺能和阿片能系统的分子变化。我们将SD大鼠急性暴露于地塞米松(一种糖皮质激素类似物)或载体，并评估了大脑皮层、纹状体和中脑中多巴胺D1和D2受体和脑啡肽的mRNA表达。地塞米松可降低大脑皮质D_1受体和脑啡肽的基因表达。在纹状体，地塞米松可降低D2受体和脑啡肽的表达，但不能降低D2受体的表达。D2受体在中脑的表达无明显变化。D_1和D_2受体基因的基本分布呈现明显的纹状体/皮质梯度，而脑啡肽基因的这种分布不明显。地塞米松可增加皮质纹状体D1和D2受体mRNA的表达。这些分子变化可能代表了对地塞米松诱导的多巴胺能和阿片能传递的增强的适应性机制，主要是在皮质区域。
In humans, glucocorticoid excess may cause neuropsychiatric symptoms, including psychosis and cognitive impairment, and glucocorticoid signaling hyperactivation may sensitize to substance of abuse. The aim of this work was to evaluate whether exposure to glucocorticoid excess triggers molecular changes in dopaminergic and opioidergic systems within relevant forebrain areas. We acutely exposed Sprague-Dawley rats to dexamethasone, a glucocorticoid analog, or vehicle and evaluated the mRNA expression of dopamine D1 and D2 receptors and enkephalin within the cortex, the striatum, and the midbrain. Dexamethasone reduced mRNA expression of D1 receptor and enkephalin in the cortex. In the striatum, dexamethasone reduced the expression of D1 receptor mRNA, but not that of D2 receptor and enkephalin. No significant changes in D2 receptor mRNA expression were observed in the midbrain. Basal distribution of D1 and D2 receptor mRNA showed a clear-cut striatal/cortical gradient, while this distribution was less obvious for enkephalin mRNA. Dexamethasone increased the cortico-striatal separation in terms of D1 and D2 receptor mRNA expression. These molecular changes may represent adaptive mechanisms to dexamethasone-induced potentiation of dopaminergic and opioidergic transmission, mostly in cortical areas.
DOI：
10.1073/pnas.0402208101
发表时间：
2004-08
影响因子：
11.1
作者：
Qiang Wei;Xin-Yun Lu;Li Liu;G. Schafer;K. Shieh;S. Burke;T. Robinson;S. Watson;A. Seasholtz;H. Akil
通讯作者：
Qiang Wei;Xin-Yun Lu;Li Liu;G. Schafer;K. Shieh;S. Burke;T. Robinson;S. Watson;A. Seasholtz;H. Akil