Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone.
Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone.
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在 ACTH 和泼尼松对照研究中治疗婴儿痉挛症婴儿结局的前瞻性研究。
DOI：
10.1016/s0022-3476(88)80318-4
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Zion,TE
中科院分区：
文献类型：
--
作者：
Glaze,DG;Hrachovy,RA;FrostJr,JD;Kellaway,P;Zion,TE
我们报告了 64 名患有婴儿痉挛症的婴儿的长期结果，并使用受控治疗计划和客观技术（24 小时脑电图和视频监测）进行前瞻性随访，以确定反应。随访时的平均年龄为 50 个月。 64 名婴儿中，三名（5%）死亡；在其他人中，41 人（67%）的发育迟缓为 50% 或以上，或者智商为 50 或以下。八名患者 (13%) 组成了我们的隐源性研究组，并根据正常 CT 扫描、婴儿痉挛症发作前的正常发育以及未确定的原因进行分类。这些患者的预后较好； 38% 发育正常或仅轻度发育迟缓。我们的症状组中，有反应者和无反应者的结果都很差：只有 5% 的人发育正常或有轻度损伤。结果不受短期与长期治疗滞后或治疗反应的显着影响。 34 名患者 (53%) 发生其他类型的癫痫发作。总之，这 64 名婴儿痉挛症患者的长期预后总体预后较差。
We report the long-term outcome of 64 infants with infantile spasms, followed prospectively, using controlled treatment schedules and objective techniques (24-hour EEG and video monitoring) to determine response. Average age at follow-up was 50 months. Of the 64 infants, three (5%) died; of the others, 41 (67%) had developmental retardation of 50% or more or an IQ of 50 or less. Eight patients (13%) composed our cryptogenic study group and were so classified on the basis of normal CT scan, normal development prior to onset of infantile spasms, and undetermined cause. These patients had the better outcome; 38% had normal development or were only mildly retarded. Both the responders and nonresponders in our symptomatic group had a poor outcome: only 5% had normal development or mild impairment. Outcome was not significantly influenced by short versus long treatment lag or by response to therapy. Other types of seizures occurred in 34 patients (53%). In summary, the overall prognosis for long-term outcome in these 64 patients with infantile spasms was poor.