The zeta cell: A new ganglion cell type in cat retina
The zeta cell: A new ganglion cell type in cat retina
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DOI：
10.1002/(sici)1096-9861(19980921)399:2
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发表时间：
1998-09
影响因子：
2.5
通讯作者：
D. Berson;M. Pu;E. Famiglietti
中科院分区：
文献类型：
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作者：
D. Berson;M. Pu;E. Famiglietti
我们通过体外细胞内染色定义了猫视网膜神经节细胞的新形态类型。 Zeta 细胞具有较小的胞体、细长的轴突和紧凑、簇状、单层的树突状乔木。猫神经节细胞的树突区域大小适中，通常是β细胞区域直径的两倍。它们在鼻视觉条纹中最小（直径<280μm），特别是在中央区域（直径60-150μm），并且在非条纹周边最大（最大直径570μm）。视野大小关于鼻颞中缝对称，但在视觉条纹附近除外，其中鼻视野小于颞视野。 Zeta 细胞树突在内部丛状层的亚层 a 和 b（OFF 和 ON 亚层）之间的边界附近分叉，占据了分隔 ON 和 OFF α 细胞树突的狭窄间隙。没有证据表明 zeta 细胞有单独的 ON 和 OFF 类型。逆行标记研究表明，位于鼻部和颞部的zeta细胞都投射到对侧上丘，而很少有投射到同侧丘或背外侧膝状核的任何细分。 Zeta 细胞的形态和投影模式表明它对应于生理学研究中的 ON-OFF 相位 W 细胞（也称为局部边缘检测器）。 Zeta 细胞在视觉条纹中具有特别小的树突状区域，可能是因为与其他神经节细胞类型相比，它们在条纹中的表现不成比例。这些条件与沿着视地平线的视网膜投影而不是主要在注视中心的最佳空间分辨率一致。雪貂、兔子和猴子的神经节细胞类型相似，这表明“zeta 样”细胞可能是哺乳动物视网膜的普遍特征。 J.Comp。内罗尔。 399:269–288, 1998。© 1998 Wiley-Liss, Inc.
We define a new morphological type of ganglion cell in cat retina by using intracellular staining in vitro. The zeta cell has a small soma, slender axon, and compact, tufted, unistratified dendritic arbor. Dendritic fields were intermediate in size among cat ganglion cells, typically twice the diameter of beta cell fields. They were smallest in the nasal visual streak (<280 μm diameter), especially near the area centralis (60–150 μm diameter), and largest in the nonstreak periphery (maximum diameter 570 μm). Fields sizes were symmetric about the nasotemporal raphe except near the visual streak, where nasal fields were smaller than temporal ones. Zeta‐cell dendrites ramified near the boundary between sublaminae a and b(OFF and ON sublayers) of the inner plexiform layer, occupying the narrow gap separating the dendrites of ON and OFF alpha cells. There was no evidence for separate ON and OFF types of zeta cell. Retrograde labeling studies revealed that both nasally and temporally located zeta cells project to the contralateral superior colliculus, whereas few project to the ipsilateral colliculus or to any subdivision of the dorsal lateral geniculate nucleus. The zeta cell's morphology and projection patterns suggest that it corresponds to the ON‐OFF phasic W‐cell (also known as the local edge detector) of physiological studies. Zeta cells have particularly small dendritic fields in the visual streak, presumably because they are disproportionately represented in the streak in comparison with other ganglion cell types. These conditions are consistent with optimal spatial resolution along the retinal projection of the visual horizon rather than principally at the center of gaze. Strong commonalities with similar ganglion cell types in ferret, rabbit, and monkey suggest that “zeta‐like” cells may be a universal feature of the mammalian retina. J. Comp. Neurol. 399:269–288, 1998. © 1998 Wiley‐Liss, Inc.