SEQUESTRATION OF STAPHYLOCOCCI AT AN INACCESSIBLE FOCUS
SEQUESTRATION OF STAPHYLOCOCCI AT AN INACCESSIBLE FOCUS
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在难以接近的焦点处隔离葡萄球菌
DOI：
10.1016/s0140-6736(79)90239-3
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
T. Beam
中科院分区：
文献类型：
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作者：
T. Beam
持续性葡萄球菌性关节炎的患者与萘夫西林是由于细胞内隔离的葡萄球菌。这些吞噬细胞内的微生物被保护免受杀菌活性。感染被利福平清除，利福平是一种能穿透白细胞膜的药物。当临床感染对看似充分的抗菌治疗没有反应时，应考虑细菌的细胞内持久性。
The persistence of staphylococcal arthritis in a patient treated with nafcillin was attributed to intracellular sequestration of staphylococci. These intraphagocytic organisms were protected against bactericidal activity. The infection was cleared by rifampin—an agent which can penetrate leucocyte membranes. When clinical infections do not respond to seemingly adequate antimicrobial treatment, intracellular persistence of bacteria should be considered.