Wide beam reconstruction "quarter-time" gated myocardial perfusion SPECT functional imaging: a comparison to "full-time" ordered subset expectation maximum
Wide beam reconstruction "quarter-time" gated myocardial perfusion SPECT functional imaging: a comparison to "full-time" ordered subset expectation maximum
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DOI：
10.1007/s12350-009-9108-7
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发表时间：
2009-10-01
影响因子：
2.4
通讯作者：
Srour, Yossi
中科院分区：
文献类型：
--
作者：
DePuey, E. Gordon;Bommireddipalli, Srinivas;Srour, Yossi
与有序子集期望最大值（OSEM）的迭代重建相比，宽波束重建（WBR）结合了分辨率恢复并在重建过程中控制了噪声，而无需应用后处理滤波器，可以在保留诊断质量的情况下进行半时间SPECT采集。我们现在假设，通过进一步的泊松噪声处理，四分之一时间的采集是可能的。基于拟人化心脏幻影数据和48例患者（pts）的试验组，对半时间WBR算法进行了四分之一时间采集优化。然后使用改进的算法，209名患者（91名男性，118名女性，平均胸围= 40英寸）在休息(R)和压力(S) （9/32 mCi Tc-99m-sestamibi）时进行全时OSEM成像，并再次使用改进的WBR算法进行四分之一次成像。获得180A度，64停，全天休息(R)（每停25秒，sps）和8帧每心动周期应激后(S) （20 sps）门控SPECT，然后获得四分之一时间R （6 sps）和S后（4 sps）门控SPECT。盲法观察者根据心肌均匀性、心内膜/心外膜边缘清晰度和背景噪声对扫描质量进行分级（1 =差至5 =优）。采用17节段模型对灌注缺损进行评分。采用三种市售软件方法，计算舒张末期容积（EDV）、收缩末期容积（ESV）和左室射血分数（LVEF）。对于209名预期患者，全日制OSEM和四分之一WBR的平均图像质量相似（3.5 +/- 0.9 vs 3.6 +/- 0.7, p NS）。对于S，四分之一时间WBR质量优于全职OSEM (4.3 +/- A 0.7 vs 3.9 +/- A 0.7) （P = 1.78 × 10(-17)）。在35名胸围超过44英寸的患者中，10 sps WBR采集改善了静息图像质量。在48名扫描异常的患者中（经OSEM扫描SSSs为bb0.2），四分之一时间WBR与全日制OSEM的平均总压力评分、总休息评分和总差异评分无显著差异（11.2 vs 10.9）、（9.1 vs 9.0）、（2.0 vs 1.9） （P NS）。在3种软件方法中，WBR与OSEM测定的LVEF、EDV和ESV具有良好的相关性（均为0.92）。WBR患者的esv通常更高，主要是由于在收缩期末期更好地描绘了瓣膜平面，而edv相似。因此，随着WBR的增加，EFs显著降低。对于灌注SPECT四分之一时间WBR提供图像质量，缺陷表征和功能评估相当于全职OSEM。
Previously we reported that compared to iterative reconstruction with ordered subset expectation maximum (OSEM), wide beam reconstruction (WBR), which incorporates resolution recovery and controls noise during reconstruction without applying a post-processing filter, allows half-time SPECT acquisition with preserved diagnostic quality. We now postulate that with further Poisson noise treatment, quarter-time acquisition is possible.The half-time WBR algorithm was optimized for quarter-time acquisition based upon anthropomorphic cardiac phantom data and a pilot group of 48 patients (pts). Then using the modified algorithm, 209 pts (91 men, 118 women, mean chest circumference = 40 in) were imaged at rest (R) and stress (S) (9/32 mCi Tc-99m-sestamibi) full-time with OSEM, and again quarter-time with the modified WBR algorithm. The 180A degrees, 64-stop, full-time single-day rest (R) (25 second-per-stop, sps) and 8-frame per cardiac cycle post-stress (S) (20 sps) gated SPECT, and then quarter-time R (6 sps) and post-S (4 sps) gated SPECT were acquired. Blinded observers graded scan quality (1 = poor to 5 = excellent) based on myocardial uniformity, endocardial/epicardial edge definition, and background noise. Perfusion defects were scored using a 17-segment model. Using three commercially available software methods, end-diastolic volume (EDV), end-systolic volume (ESV), and left ventricular ejection fraction (LVEF) were calculated.For the 209 prospective pts, mean image quality for R full-time OSEM and quarter-time WBR were similar (3.5 +/- A 0.9 vs 3.6 +/- A 0.7, p NS). For S, quarter-time WBR quality was superior to full-time OSEM (4.3 +/- A 0.7 vs 3.9 +/- A 0.7) (P = 1.78 x 10(-17)). In 35 pts with chest circumferences > 44 inches a longer, 10 sps WBR acquisition improved resting image quality. Of 48 pts with abnormal scans (SSSs > 2 by OSEM) mean summed stress scores, summed rest scores, and summed difference scores were not significantly different with quarter-time WBR vs full-time OSEM (11.2 vs 10.9), (9.1 vs 9.0), (2.0 vs 1.9) (P NS). For the three software methods, there was a good correlation of LVEF, EDV, and ESV determined by WBR vs OSEM (all r > 0.92). ESVs were generally higher with WBR, primarily due to better delineation of the valve plane at end-systole, whereas EDVs were similar. Thus, EFs were significantly lower with WBR.For perfusion SPECT quarter-time WBR affords image quality, defect characterization, and functional assessment equivalent to full-time OSEM.