Exercise stress increases susceptibility to influenza infection
Exercise stress increases susceptibility to influenza infection
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DOI：
10.1016/j.bbi.2008.06.004
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发表时间：
2008-11-01
影响因子：
15.1
通讯作者：
Mayer, E. P.
中科院分区：
文献类型：
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作者：
Murphy, E. A.;Davis, J. M.;Mayer, E. P.
运动压力与上呼吸道感染（URTI）的风险增加有关，而适度运动则与风险降低有关。我们已经表明，运动应激可增加对1型单纯疱疹病毒呼吸道感染的易感性（发病率、症状严重程度和死亡率），但几乎没有证据表明应激性运动对人类呼吸道感染主要病原的易感性的影响，包括流感病毒。本研究考察了应激性运动对流感病毒易感性的影响（A/Puerto Rico/8/34 (H1N1)）。小鼠被分为两组：运动组（前）和对照组（后）。运动包括连续三天在跑步机上跑到意志疲劳（类似于120分钟）。在最后一轮运动或休息后15分钟，给小鼠（n = 20-21/组）鼻内接种标准剂量的流感病毒（0.25 HAU）。每天监测小鼠的发病率（发病时间）、症状严重程度和死亡率（死亡时间），持续21天。运动应激与感染易感性增加相关（第6天和第7天的发病率、死亡率和症状严重程度；P < 0.05）。这些数据来自一个受控制的流感病毒挑战模型，这大大增加了越来越多的证据，即剧烈运动可以增加对尿路感染的易感性。(C) 2008爱思唯尔公司版权所有。
Exercise stress is associated with an increased risk for upper respiratory tract infection (URTI) while moderate exercise has been associated with a decreased risk. We have shown that exercise stress can increase susceptibility (morbidity, symptom severity and mortality) to HSV-1 respiratory infection, but there is little evidence on the effects of stressful exercise on susceptibility to the principal etiological agents of human respiratory infections, including influenza viruses. This study examined the effects of stressful exercise on susceptibility to influenza virus (A/Puerto Rico/8/34 (H1N1)). Mice were assigned to one of two groups: exercise (Ex) or control (Con). Exercise consisted of a treadmill run to volitional fatigue (similar to 120 min) performed on three consecutive days. Fifteen minutes after the last bout of exercise or rest, mice (n = 20-21/group) were intranasally inoculated with a standardized dose of influenza virus (0.25 HAU). Mice were monitored daily for morbidity (time to sickness), symptom severity and mortality (time to death) for 21 days. Exercise stress was associated with an increase in susceptibility to infection (morbidity, mortality and symptom severity on days 6 and 7; P < 0.05). These data from a controlled influenza virus challenge model add significantly to the growing body of evidence that severe exercise can increase susceptibility to URTI. (C) 2008 Elsevier Inc. All rights reserved.