Prospective cohort study of the risk of prostate cancer among rotating-shift workers: Findings from the Japan Collaborative Cohort Study
Prospective cohort study of the risk of prostate cancer among rotating-shift workers: Findings from the Japan Collaborative Cohort Study
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DOI：
10.1093/aje/kwj232
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发表时间：
2006-09-15
影响因子：
5
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Kubo, Tatsuhiko;Ozasa, Kotaro;Tamakoshi, Akiko
据报道，轮班工人患某些癌症的风险增加。然而，以前没有研究过轮班工人患前列腺癌的风险。这项研究前瞻性地研究了倒班工作与前列腺癌发病率之间的关系，研究对象为14,052名日本男性工人，他们参加了一个大规模的前瞻性队列研究。1988年至1990年进行了基线调查。受试者被要求指出他们以前从事的最有规律的工作时间表：白天工作，轮班工作或固定夜间工作。在111，974人-年期间，记录了31例前列腺癌病例。采用考克斯比例风险模型估计风险，并对年龄、前列腺癌家族史、调查的研究区域、体重指数、吸烟、饮酒、工作类型、工作时的体力活动、工作场所、感知压力、教育水平和婚姻状况进行调整。与白班工人相比，夜班工人患前列腺癌的风险显著（相对风险= 3.0，95%置信区间：1.2，7.7），而固定夜班工作与风险的小幅和非显著性增加相关。这份报告是第一份揭示倒班工作与前列腺癌之间显著关系的报告。
Shift workers have been reported to have an increased risk of some cancers. However, the risk of prostate cancer in shift workers is not known to have been examined previously. This study prospectively examined the association between shift work and risk of prostate cancer incidence among 14,052 working men in Japan enrolled in a large-scale prospective cohort. A baseline survey was conducted between 1988 and 1990. Subjects were asked to indicate the most regular work schedule they had undertaken previously: day work, rotating-shift work, or fixed-night work. During 111,974 person-years, 31 cases of prostate cancer were recorded. The Cox proportional hazards model was used to estimate the risk, with adjustments for age, family history of prostate cancer, study area surveyed, body mass index, smoking, alcohol drinking, job type, physical activity at work, workplace, perceived stress, educational level, and marriage status. Compared with day workers, rotating-shift workers were significantly at risk for prostate cancer (relative risk = 3.0, 95% confidence interval: 1.2, 7.7), whereas fixed-night work was associated with a small and nonsignificant increase in risk. This report is the first known to reveal a significant relation between rotating-shift work and prostate cancer.