Exosomal integrins and their influence on pancreatic cancer progression and metastasis
Exosomal integrins and their influence on pancreatic cancer progression and metastasis
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DOI：
10.1016/j.canlet.2021.03.010
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发表时间：
2021-03-25
期刊：
影响因子：
9.7
通讯作者：
Falasca, Marco
中科院分区：
文献类型：
--
作者：
Casari, Ilaria;Howard, Justin Andrew;Falasca, Marco
作为迄今为止最致命和最无法治疗的癌症类型之一，胰腺癌并没有从研究进展中受益。尽管所有的努力，这种恶性肿瘤仍然很难及时诊断，耐药治疗，并容易复发。转移的出现是众所周知的难以对抗和不幸的肿瘤的信号是每个癌症患者最害怕的事情，尤其是那些患有胰腺癌的人。早期发现和治疗转移瘤的策略是有限的，新的行动计划正在急切地等待。最近，细胞分泌的囊泡或外泌体在细胞-细胞通讯中的重要性，特别是它们在促进病理状况（如传染病和癌症）中的关键作用，引起了科学界的关注。一些外泌体膜成分的发现，如粘附受体和整合素，以及它们影响癌细胞功能和转移进展的能力，增加了对转移过程的一些重要理解，并有望为开发用于识别和靶向转移的新工具打开大门。本文就整合素在外泌体介导的胰腺癌进展和转移中的作用进行综述。
As one of the most lethal and untreatable types of cancer so far, pancreatic cancer is not benefitting from advancements in research. Despite all the efforts, this malignancy is still very difficult to diagnose in time, resistant to treatments, and prone to relapses. The appearance of metastasis-notoriously difficult to fight and a signal of unfortunate prognosis-is the event most dreaded by every cancer patient, especially by those with pancreatic cancer. Strategies for early detection and treatment of metastases are limited, and new action plans are desperately awaited. Recently, the importance of cell-secreted vesicles, or exosomes, in cell-cell communication and, particularly, their key role in promoting pathological conditions, such as infectious diseases and cancer, have attracted the attention of the scientific community. The discovery of some exosome membrane components, such as adhesion receptors and integrins, and their ability to influence cancer cell functions and metastasis progression, has added some important understanding of the metastatic process and will hopefully open the door to the development of new tools for identifying and targeting metastases. The aim of this review is to discuss the role played by integrins in exosomal-mediated pancreatic cancer progression and metastasis.