Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation
Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation
复制标题
DOI：
10.1038/sj.jea.7500449
复制
发表时间：
2006-03-01
影响因子：
4.5
通讯作者：
Graziano, J
中科院分区：
文献类型：
--
作者：
Ahsan, H;Chen, Y;Graziano, J
砷对健康的影响纵向研究（HEALS），一个多学科和大型前瞻性队列研究，在Araihazar，孟加拉国，建立了全剂量范围的砷（As）暴露对各种健康结果的影响，包括癌前和恶性皮肤肿瘤，总死亡率，妊娠结局和儿童的认知发育。在本文中，我们提供了研究方法的描述，包括研究设计，研究人群，数据收集，反应率，暴露和结局评估。我们还介绍了研究参与者的特征，包括基线招募时的暴露分布和皮肤病变的患病率。共有11，746名18至75岁的已婚男性和女性参与了基线研究（回复率为98%），并完成了完整的问卷调查，其中包括食物频率问卷，回复率为98%。在98%完成临床评价的参与者中，超过90%提供了血液样本和现场尿液样本。较高的教育程度、男性、癌前皮肤病变与提供血液和尿液样本的可能性增加相关。年龄较大的参与者不太可能捐献血液样本。大约三分之一的参与者从三组中的每一组中饮用砷浓度的井水：> 100 μ g/l，25-100 μ g/l和< 25 μ g/l。男性和女性的平均尿砷浓度分别为140和136微克/升。HEALS有几个独特的功能，包括一个前瞻性的研究设计，全面评估过去和未来的变化，在个人水平上，生物样本的大型储存库，并在研究人群中作为曝光的全剂量范围。HEALS是一个有价值的资源，用于研究As暴露对健康影响的新研究问题。
Health Effects of Arsenic Longitudinal Study ( HEALS), a multidisciplinary and large prospective cohort study in Araihazar, Bangladesh, was established to evaluate the effects of full-dose range arsenic ( As) exposure on various health outcomes, including premalignant and malignant skin tumors, total mortality, pregnancy outcomes, and children's cognitive development. In this paper, we provide descriptions of the study methods including study design, study population, data collection, response rates, and exposure and outcome assessments. We also present characteristics of the study participants including the distribution of exposure and the prevalence of skin lesion at baseline recruitment. A total of 11,746 marriedmen and women between 18 and 75 years of age participated in the study at baseline ( a response rate of 98%) and completed a full questionnaire interview that included a food frequency questionnaire, with a response rate of 98%. Among the 98% of the participants who completed the clinical evaluation, over 90% provided blood samples and spot urine samples. Higher educational status, male gender, and presence of premalignant skin lesions were associated with an increased likelihood of providing blood and urine samples. Older participants were less likely to donate a blood sample. About one-third of the participants consumed water from a well with As concentration in each of three groups: > 100 mu g/l, 25-100 mu g/l, and < 25 mu g/l. Average urinary As concentrations were 140 and 136 mu g/l for males and females, respectively. HEALS has several unique features, including a prospective study design, comprehensive assessments of both past and future changes in As exposure at the individual level, a large repository of biological samples, and a full dose range of As exposures in the study population. HEALS is a valuable resource for examining novel research questions on the health effects of As exposure.