Increased levels of endothelial microparticles CD144 (VE-Cadherin) positives in type 2 diabetic patients with coronary noncalcified plaques evaluated by multidetector computed tomography (MDCT)
Increased levels of endothelial microparticles CD144 (VE-Cadherin) positives in type 2 diabetic patients with coronary noncalcified plaques evaluated by multidetector computed tomography (MDCT)
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DOI：
10.1016/j.atherosclerosis.2008.07.039
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发表时间：
2009-04-01
期刊：
影响因子：
5.3
通讯作者：
Douek, Philippe
中科院分区：
文献类型：
--
作者：
Bernard, Sophie;Loffroy, Romaric;Douek, Philippe
目的：亚临床动脉粥样硬化的形态学和细胞标志物的组合，除了传统的危险因素，可能有助于改善2型糖尿病患者的心血管预防。我们的横断面研究的目的是证明一个假定的增加内皮细胞（EMP）或血小板（PMP）微粒，在2型糖尿病患者冠状动脉非钙化斑块检测多排CT（MDCT）。方法和结果：微粒和冠状动脉MDCT进行了评估，在56例2型糖尿病患者不同的心血管风险水平。EMP（r = 0.35，p = 0.022）和PMP（rho = 0.34，p = 0.022）均与hsCRP相关。EMP在急性冠状动脉综合征患者中升高（p = 0.034）。非钙化病变节段的EMP计数显著较高（p = 0.01）。相比之下，hsCRP和非钙化性动脉粥样硬化之间没有关联。在校正冠心病和hsCRR后，非钙化病变节段携带者的EMP增加仍具有边缘显著性。相反，PMP计数与非钙化病变节段无关，急性冠状动脉综合征患者和非急性冠状动脉综合征患者的PMP计数无差异。EMP和PMP计数与混合或钙化病变节段之间没有显著相关性。结论：我们首次报道了在2型糖尿病患者人群中通过MDCT评估血浆EMP-CD 144+与冠状动脉非钙化斑块之间的相关性。EMP可作为不稳定斑块的替代标记物，有助于提高中度危险糖尿病患者心血管疾病的预测。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Objective: The combination of both morphological and cellular markers of subclinical atherosclerosis, in addition to conventional risk factors, may help to improve cardiovascular prevention in type 2 diabetic patients. The aim of our cross-sectional study was to evidence a putative increase in endothelial (EMP) or platelet (PMP) microparticles, in type 2 diabetic patients with coronary noncalcified plaques detected by multidetector CT (MDCT).Methods and results: Microparticles and coronary MDCT were assessed in 56 type 2 diabetic patients with different cardiovascular risk levels. Both EMP (r = 0.35, p = 0.022) and PMP (rho = 0.34, p = 0.022) were correlated with hsCRP. EMP were elevated in patients with acute coronary syndromes (p = 0.034). EMP count was significantly higher in the presence of noncalcified diseased segments (p = 0.01). By contrast, there was no association between hsCRP and noncalcified atheroma. This increase in EMP in noncalcified diseased segment carriers remained borderline significant after adjustment for coronary heart disease and hsCRR Conversely, there was no association of PMP count with noncalcified diseased segments and no difference in PMP count between patients with and without acute coronary syndrome. No significant association between either EMP and PMP counts and mixed or calcified diseased segments was observed. Conclusions: We report for the first time an association between plasma EMP-CD144+ and coronary noncalcified plaques assessed by MDCT in a Population of type 2 diabetic patients. EMP might be used as a Surrogate marker of unstable plaques, and might help to improve cardiovascular prediction in diabetic patients with intermediate risk. (C) 2008 Elsevier Ireland Ltd. All rights reserved.