Plasmodium falciparum malaria: band 3 as a possible receptor during invasion of human erythrocytes.
Plasmodium falciparum malaria: band 3 as a possible receptor during invasion of human erythrocytes.
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恶性疟原虫疟疾：带 3 作为入侵人类红细胞期间可能的受体。
DOI：
10.1126/science.3880920
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Bennett,V
中科院分区：
文献类型：
--
作者：
Okoye,VC;Bennett,V
人红细胞带 3（一种主要的跨膜蛋白）被纯化并掺入脂质体中。这些脂质体在纳摩尔浓度的蛋白质下，可在体外抑制疟原虫恶性疟原虫对人红细胞的侵袭。含有人带3的脂质体抑制侵袭的效果比含有猪带3的脂质体高10倍，比含有人红细胞血型糖蛋白的脂质体高6倍。单独的脂质体或含有红细胞糖脂的脂质体不抑制侵袭。这些结果表明，带 3 参与入侵过程的一个步骤涉及带 3 与寄生虫的某些成分之间的特异性、高亲和力相互作用。
Human erythrocyte band 3, a major membrane-spanning protein, was purified and incorporated into liposomes. These liposomes, at nanomolar concentrations of protein, inhibited invasion of human erythrocytes in vitro by the malaria parasitePlasmodium falciparum. Liposomes containing human band 3 were ten times more effective in inhibiting invasion than those with pig band 3 and six times more effective than liposomes containing human erythrocyte glycophorin. Liposomes alone or liposomes containing erythrocyte glycolipids did not inhibit invasion. These results suggest that band 3 participates in the invasion process in a step involving a specific, high-affinity interaction between band 3 and some component of the parasite.