MYC-Driven Pathways in Breast Cancer Subtypes.
MYC-Driven Pathways in Breast Cancer Subtypes.
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DOI：
10.3390/biom7030053
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发表时间：
2017-07-11
期刊：
影响因子：
5.5
通讯作者：
Shajahan-Haq AN
中科院分区：
文献类型：
--
作者：
Fallah Y;Brundage J;Allegakoen P;Shajahan-Haq AN
转录因子MYC （MYC原癌基因，bHLH转录因子）是维持多种类型癌症生长的多种细胞过程中必不可少的信号中枢。MYC调节RNA的表达，包括蛋白质和非编码RNA，这些RNA控制中枢代谢途径、细胞死亡、增殖、分化、应激途径和耐药机制。MYC的激活在乳腺癌进展中已被广泛报道。乳腺癌是一种复杂的异质性疾病，治疗方案主要由肿瘤的组织学和生化评估指导。根据生化指标，乳腺癌主要分为ER+（雌激素受体α阳性）、HER2+（人表皮生长因子受体2阳性）和TNBC（三阴性乳腺癌，雌激素受体阴性、孕激素受体阴性、HER2阴性）三大类。与其他癌症亚型相比，TNBC中MYC升高。有趣的是，myc驱动通路在侵袭性乳腺癌细胞和显示耐药表型的肿瘤中进一步升高。鉴定MYC靶基因对于分离驱动肿瘤发展的信号通路至关重要。在这篇综述中，我们讨论了MYC在三种主要乳腺癌亚型中的作用，并强调了最有希望靶向MYC功能的线索。
The transcription factor MYC (MYC proto-oncogene, bHLH transcription factor) is an essential signaling hub in multiple cellular processes that sustain growth of many types of cancers. MYC regulates expression of RNA, both protein and non-coding, that control central metabolic pathways, cell death, proliferation, differentiation, stress pathways, and mechanisms of drug resistance. Activation of MYC has been widely reported in breast cancer progression. Breast cancer is a complex heterogeneous disease and treatment options are primarily guided by histological and biochemical evaluations of the tumors. Based on biochemical markers, three main breast cancer categories are ER+ (estrogen receptor alpha positive), HER2+ (human epidermal growth factor receptor 2 positive), and TNBC (triple-negative breast cancer; estrogen receptor negative, progesterone receptor negative, HER2 negative). MYC is elevated in TNBC compared with other cancer subtypes. Interestingly, MYC-driven pathways are further elevated in aggressive breast cancer cells and tumors that display drug resistant phenotype. Identification of MYC target genes is essential in isolating signaling pathways that drive tumor development. In this review, we address the role of MYC in the three major breast cancer subtypes and highlight the most promising leads to target MYC functions.
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影响因子：
45.3
作者：
Buzdar, A;Jonat, W;Plourde, PV
通讯作者：
Plourde, PV
影响因子：
5.7
作者：
Gross, Matt I.;Demo, Susan D.;Bennett, Mark K.
通讯作者：
Bennett, Mark K.
DOI：
10.1158/1055-9965.epi-13-0584
发表时间：
2013-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Liesenfeld DB;Habermann N;Owen RW;Scalbert A;Ulrich CM
通讯作者：
Ulrich CM
影响因子：
--
作者：
Hammond, M. Elizabeth H.;Hayes, Daniel F.;Temin, Sarah
通讯作者：
Temin, Sarah
DOI：
10.14694/edbook_am.2014.34.e497
发表时间：
2014
期刊：
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
影响因子：
--
作者：
Horiuchi D;Anderton B;Goga A
通讯作者：
Goga A