The Effect of Gastric pH on the Pharmacokinetics-Pharmacodynamics of Naphthoquine in Rodents, as well as in Human Predicted Using a PBPK Model.
The Effect of Gastric pH on the Pharmacokinetics-Pharmacodynamics of Naphthoquine in Rodents, as well as in Human Predicted Using a PBPK Model.
复制标题
使用 PBPK 模型预测胃 pH 值对萘酚喹在啮齿类动物以及人类中的药代动力学-药效学的影响。
DOI：
10.2174/1389200222666210129102411
复制
发表时间：
2021-01
影响因子：
2.3
通讯作者：
Xing Jie
中科院分区：
文献类型：
--
作者：
Xie Yuewu;Liu Huixiang;Chen Xiaoyue;Xing Jie
BACKGROUND Fixed-dose combination of artemisinin and naphthoquine (NQ) is a new artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum. NQ absorption has been reported to be affected by food in human. OBJECTIVES T
