Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries
Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries
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DOI：
10.1590/1516-4446-2019-0761
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发表时间：
2020-08-01
影响因子：
5.5
通讯作者：
Mari, Jair de J.
中科院分区：
文献类型：
--
作者：
Cirillo, Alessandra;Diniz, Elton;Mari, Jair de J.
目的：群体神经科学是一个新兴领域，它将流行病学和神经科学结合起来，研究基因和环境如何塑造典型和非典型的大脑功能。本研究的目的是回顾低收入和中等收入国家 (LMIC) 的人口神经科学关键研究，并确定与高收入国家进行的研究之间的潜在差距。方法：我们进行了系统回顾，寻找调查中低收入国家儿童和青少年精神疾病发展的纵向队列研究。我们在 EMBASE 和 MEDLINE 数据库中从一开始到 2019 年 7 月 5 日进行了电子检索。结果：我们发现了来自四个国家的 6 个队列符合我们的检索标准：3 个队列来自巴西，1 个队列来自中国，1 个队列来自南非，1 个队列来自毛里求斯。报告了这些研究结果的相关示例。结论：我们的结果证明了这些队列设计所促进的有价值的科学产出的影响，使中低收入国家能够在全球精神病学研究的前沿中分享。国家和国际资助机构应投资于中低收入国家人口神经科学，以促进高收入国家研究的复制和推广。
Objective: Population neuroscience is an emerging field that combines epidemiology and neuroscience to study how genes and the environment shape typical and atypical brain functioning. The objective of this study was to review key studies on population neuroscience from low- and middle-income countries (LMICs) and to identify potential gaps vis-a-vis studies conducted in high-income countries.Methods: We conducted a systematic review to search for longitudinal cohort studies investigating the development of psychiatric disorders in children and adolescents in LMICs. We performed an electronic search in the EMBASE and MEDLINE databases from inception to July 5th, 2019.Results: We found six cohorts from four countries that met our search criteria: three cohorts from Brazil, one from China, one from South Africa, and one from Mauritius. Relevant examples of findings from these studies are reported.Conclusion: Our results demonstrate the impact of the valuable science output these cohort designs promote, allowing LMICs to have a share in frontline global psychiatry research. National and international funding agencies should invest in LMIC population neuroscience in order to promote replication and generalization of research from high-income countries.