Comparative simulations of aquaporin family: AQP1, AQPZ, AQP0 and GlpF
Comparative simulations of aquaporin family: AQP1, AQPZ, AQP0 and GlpF
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DOI：
10.1016/j.febslet.2005.09.018
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发表时间：
2005-10-24
期刊：
影响因子：
3.5
通讯作者：
Kidera, A
中科院分区：
文献类型：
--
作者：
Hashido, M;Ikeguchi, M;Kidera, A
对水通道蛋白家族的4个成员（AQP1、AQPZ、AQP0和GlpF）在外膜环境中进行了分子动力学模拟。单通道渗透率p(f)为与AQPZ > AQP1 >> AQP0相似的GlpF，相对孔径为GlpF >> AQP1 > AQPZ > AQP0。pf与孔隙大小的关系表明，渗透率不仅取决于通道半径，还与其他竞争因素有关。水动力学分析表明，该因子为水输运的单纵队性质。(c) 2005年由Elsevier B.V.代表欧洲生化学会联合会出版。
Molecular dynamics simulations were performed for four members of the aquaporin family (AQP1, AQPZ, AQP0, and GlpF) in the explicit membrane environment. The single-channel water permeability, p(f), was evaluated to be GlpF similar to AQPZ > AQP1 >> AQP0, while their relative pore sizes were GlpF >> AQP1 > AQPZ > AQP0. This relation between pf and pore size indicates that water permeability was determined not only by the channel radius, but also another competing factor. Analysis of water dynamics revealed that this factor was the single-file nature of water transport. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.