Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease.
Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease.
复制标题
2型糖尿病和慢性肾脏疾病的患者的血清乳糖素-9水平升高。
DOI：
10.1186/1471-2369-14-23
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发表时间：
2013-01-22
期刊：
影响因子：
2.3
通讯作者：
Makino H
中科院分区：
文献类型：
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作者：
Kurose Y;Wada J;Kanzaki M;Teshigawara S;Nakatsuka A;Murakami K;Inoue K;Terami T;Katayama A;Watanabe M;Higuchi C;Eguchi J;Miyatake N;Makino H
半乳糖凝集素-9(Galectin-9，Gal-9)作为T细胞免疫球蛋白粘蛋白-3(Tim-3，TIM-3)的配体，可诱导活化的辅助性T细胞(TH1)的凋亡。Gal-9还通过逆转高糖诱导的细胞周期依赖性激酶抑制物如p27Kip1和p21Cip1的上调，抑制db/db小鼠的G1期细胞周期停滞和肥大，这是早期糖尿病肾病的标志。本文对182例慢性肾脏病(CKD)不同分期的2型糖尿病患者血清Gal-9水平进行了检测。2型糖尿病患者血清Gal-9水平为131.9±105.4 pg/ml，与年龄(r=0.227，p=0.002)、肌酐(r=0.175，p=0.018)、尿素氮(r=0.162，p=0.028)、渗透压(r=0.187，p=0.014)呈显著正相关，与估计肾小球滤过率呈负相关(r=−0.188，p=0.011)。Log10Gal-9水平随肾小球滤过率G1~G4的增加而升高，经t检验有统计学意义(p=0.012)。在A1到A3的蛋白尿期，Log10Gal-9的水平保持在相似的水平。2型糖尿病患者血清Gal-9水平升高与肾小球滤过率密切相关，可能与2型糖尿病和慢性肾脏病患者免疫反应和炎症反应的改变有关。
Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (TH1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of cyclin dependent kinase inhibitors such as p27Kip1 and p21Cip1. We investigated the serum levels of Gal-9 in the patients with type 2 diabetes and various stages of chronic kidney disease (CKD) (n=182). Serum Gal-9 levels in the patients with type 2 diabetes were 131.9 ± 105.4 pg/ml and Log10Gal-9 levels significantly and positively correlated with age (r=0.227, p=0.002), creatinine (r=0.175, p=0.018), urea nitrogen (r=0.162, p=0.028) and osmotic pressure (r=0.187, p=0.014) and negatively correlated with estimated glomerular filtration rate (eGFR) (r=−0.188, p=0.011). Log10Gal-9 levels increased along with the progression of GFR categories of G1 to G4, and they were statistically significant by Jonckheere-Terpstra test (p=0.012). Log10Gal-9 levels remained similar levels in albuminuria stages of A1 to A3. The elevation of serum Gal-9 in the patients with type 2 diabetes is closely linked to GFR and they may be related to the alteration of the immune response and inflammation of the patients with type 2 diabetes and CKD.