Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay
Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay
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DOI：
10.1128/jb.01189-07
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发表时间：
2008-05-01
影响因子：
3.2
通讯作者：
Galyov, Edouard E.
中科院分区：
文献类型：
--
作者：
Field, Terry R.;Layton, Abigail N.;Galyov, Edouard E.
我们筛选了5700个肠沙门氏菌血清鼠伤寒沙门氏菌突变体，寻找III型分泌系统1 （T3SS-1）介导的接触依赖性溶血缺陷，以确定影响T3SS-1活性的新基因和途径。我们的数据表明，以前未被认识的因素，如I型菌毛可能会调节这一关键毒力因子的表达、活性或部署。
We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.