Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism.
Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism.
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Muscleblind-like 2：哺乳动物松果体中的昼夜节律表达受肾上腺素cAMP机制控制。
DOI：
10.1111/j.1471-4159.2009.06184.x
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发表时间：
2009
影响因子：
4.7
通讯作者：
Klein,DavidC
中科院分区：
文献类型：
--
作者：
Kim,Jong-So;Coon,StevenL;Weller,JoanL;Blackshaw,Seth;Rath,MartinF;Møller,Morten;Klein,DavidC
Muscleblind-like 2 (Mbnl2) 是一种首先在果蝇中发现的锌指蛋白。它似乎对于光感受器发育至关重要并参与 RNA 剪接。在这里，我们报道 Mbnl2 在大鼠松果体中强烈表达。松果体 Mbnl2 转录物的丰度遵循明显的昼夜节律，夜间峰值水平比白天高约七倍。 Mbnl2 蛋白表现出相似的节律。体外研究表明，Mbnl2 转录物和蛋白的丰度受肾上腺素能/cAMP 机制控制。
Muscleblind‐like 2 (Mbnl2) is a zinc finger protein first identified inDrosophila.It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report thatMbnl2is strongly expressed in the rat pineal gland. The abundance of pineal Mbnl2 transcripts follows a marked circadian rhythm with peak levels approximately sevenfold higher at night than day levels. Mbnl2 protein exhibits a similar rhythm.In vitrostudies indicate that the abundance of Mbnl2 transcripts and protein are controlled by an adrenergic/cAMP mechanism.