Risk of lung cancer among patients with head and neck cancer.
Risk of lung cancer among patients with head and neck cancer.
复制标题
头颈癌患者罹患肺癌的风险。
DOI：
10.1016/s0194-59989770239-0
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Thomas,DB
中科院分区：
文献类型：
--
作者：
Deleyiannis,FW;Thomas,DB
华盛顿州西部监测、流行病学和最终结果区肿瘤登记的5180名头颈部癌症患者接受了长达15年的跟踪调查，以确定患肺癌的风险。对这一队列中的522名患者进行了样本访谈，以确定吸烟史。在5180例患者中，356例(6.9%)发展为肺癌。在15年的随访中，肺癌的总年发病率保持相对稳定，大约在1.0%到2.0%之间。男性患肺癌的风险比女性高(相对风险(RR)=1.56；95%可信区间(CI)=1.18-2.03)。与口腔癌比较(RR=1.00)，唇癌发生肺癌的相对危险度为0.63(95%CI=0.40~0.98)，内喉癌的相对危险度为1.12(95%CI=0.81~1.56)，口咽癌的相对危险度为1.73(95%CI=1.21~2.47)，下咽癌的相对危险度为1.84(95%CI=1.16~2.92)，外喉癌的相对危险度为2.28(95%CI=1.60~3.24)。在接受采访的522名患者中，男性比女性吸烟更多(p<；0.0001)，喉癌或咽癌患者比唇癌或口腔癌患者吸烟更多(p>；0.05)。在头颈癌患者中，男性以及咽癌或外源性喉癌患者患肺癌的风险最高。这些发现可能可以用吸烟消费的差异来解释。
A cohort of 5180 patients with head and neck cancer, who were part of the tumor registry of the Surveillance, Epidemiology, and End Results area of western Washington State, was followed up for as many as 15 years to determine the risk of lung cancer. A sample of 522 patients from this cohort was interviewed to determine smoking history. Lung cancer developed in 356 (6.9%) of the 5180 patients. The overall annual incidence of lung cancer remained relatively constant between approximately 1.0% and 2.0% during the 15 years of follow-up. Men had an increased risk of lung cancer compared with women (relative risk (RR) = 1.56; 95% confidence interval (CI) = 1.18 to 2.03). Compared with patients with oral cavity cancer (RR = 1.00), the relative risk of lung cancer developing by the site of the index tumor was 0.63 (95% CI = 0.40 to 0.98) for lip, 1.12 (95% CI = 0.81 to 1.56) for intrinsic larynx, 1.73 (95% CI = 1.21 to 2.47) for oropharynx, 1.84 (95% CI = 1.16 to 2.92) for hypopharynx, and 2.28 (95% CI = 1.60 to 3.24) for extrinsic larynx. Among the 522 patients who were interviewed, men smoked more than women (p < 0.0001), and patients with laryngeal or pharyngeal cancer smoked more than patients with cancer of the lip or the oral cavity (p > 0.05). Among patients with head and neck cancer, the risk of lung cancer is highest for men and for patients with cancer of the pharynx or extrinsic larynx. These findings may be explained by differences in smoking consumption.