Dual time point 18F-FDG PET imaging detects breast cancer with high sensitivity and correlates well with histologic subtypes.
Dual time point 18F-FDG PET imaging detects breast cancer with high sensitivity and correlates well with histologic subtypes.
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发表时间：
2006-09
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通讯作者：
A. Mavi;M. Urhan;J. Yu;H. Zhuang;M. Houseni;T. Çermik;Dhurairaj Thiruvenkatasamy;B. Czerniecki;M. Schnall;A. Alavi
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作者：
A. Mavi;M. Urhan;J. Yu;H. Zhuang;M. Houseni;T. Çermik;Dhurairaj Thiruvenkatasamy;B. Czerniecki;M. Schnall;A. Alavi
这项前瞻性研究旨在评估 (18)F-FDG PET 双时间点成像技术在检测原发性乳腺癌中的实用性，并确定 (18)F-FDG 摄取及其随时间的变化与组织病理学亚型之间是否存在关系。方法 152 名新诊断乳腺癌患者接受了 2 次连续 PET 扫描（双时间点成像）以进行术前分期。从两个时间点测量 (18)F-FDG 的最大标准化摄取值 (SUVmax)。计算时间点 1 (SUVmax1) 和 2 (SUVmax2) 之间 SUVmax 的百分比变化 (Delta%SUVmax)。根据组织病理学将患者分为侵袭性和非侵袭性两组。侵袭性肿瘤也分为两组（>10mm和4-10mm）。测量各组两个时间点的肿瘤与对侧正常乳腺（背景）的 SUVmax 比率，并计算 Delta%SUVmax 值。结果 SUVmax1、SUVmax2 和 Delta%SUVmax 的平均值 +/- SD 为 3.9 +/- 3.7、4.3 +/- 4.0 和 8.3% +/- 11.5%（侵入性）；非侵入性为 2.0 +/- 0.6、2.1 +/- 0.6 和 3.4% +/- 13.0%；对侧正常乳房组的比率分别为 1.2 +/- 0.3、1.1 +/- 0.2 和 -10.0% +/- 10.8%。在各组间 SUVmax1、Delta%SUVmax 和肿瘤与背景比的比较中，所有结果均显着（P 10 mm，4-10 mm 浸润性乳腺癌为 82.7%，非浸润性乳腺癌为 76.9%。结论 双时间点成像是一种简单且无创的方法，可以提高 (18)F-FDG PET 评估的灵敏度和准确性 原发性乳腺癌患者。双时间点成像中 SUV 中注意到的变化取决于原发性乳腺癌的组织病理学类型。
UNLABELLED This prospective study was designed to assess the utility of the dual time point imaging technique by (18)F-FDG PET in detecting primary breast cancer and to determine whether there is a relationship between (18)F-FDG uptake and its change over time and the histopathologic subtypes. METHODS One hundred fifty-two patients with newly diagnosed breast cancer underwent 2 sequential PET scans (dual time point imaging) for preoperative staging. The maximum standardized uptake value (SUVmax) of (18)F-FDG was measured from both time points. The percent change in SUVmax (Delta%SUVmax) between time points 1 (SUVmax1) and 2 (SUVmax2) was calculated. Patients were divided into 2 groups according to histopathology as invasive and noninvasive. Invasive tumors were also divided into 2 groups (>10 mm and 4-10 mm). The tumor-to-contralateral normal breast (background) ratios of SUVmax at both time points for groups were measured and the Delta%SUVmax values were calculated. RESULTS The mean +/- SD of the SUVmax1, the SUVmax2, and the Delta%SUVmax were 3.9 +/- 3.7, 4.3 +/- 4.0, and 8.3% +/- 11.5% for invasive; 2.0 +/- 0.6, 2.1 +/- 0.6, and 3.4% +/- 13.0% for noninvasive; and were 1.2 +/- 0.3, 1.1 +/- 0.2, and -10.0% +/- 10.8% for the contralateral normal breast groups, respectively. In the comparison of SUVmax1, Delta%SUVmax, and the tumor-to-background ratios among groups, all results were significant (P 10 mm, 82.7% for invasive breast cancers 4-10 mm, and 76.9% for noninvasive breast cancers. CONCLUSION Dual time point imaging is a simple and noninvasive method that may improve the sensitivity and accuracy of (18)F-FDG PET in assessing patients with primary breast cancer. The changes that are noted in SUVs in dual time point imaging vary depending on the histopathologic type of primary breast cancer.