BENZODIAZEPINE-INDUCED OUTCOME REVALUATION AND THE MOTIVATIONAL CONTROL OF INSTRUMENTAL ACTION IN RATS
BENZODIAZEPINE-INDUCED OUTCOME REVALUATION AND THE MOTIVATIONAL CONTROL OF INSTRUMENTAL ACTION IN RATS
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DOI：
10.1037/0735-7044.108.3.573
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发表时间：
1994-06-01
影响因子：
1.9
通讯作者：
DICKINSON, A
中科院分区：
文献类型：
--
作者：
BALLEINE, B;BALL, J;DICKINSON, A
有人认为，动机状态对工具行为的控制是间接的，由这些状态对工具结果的激励价值的影响来调节（A. Dickinson & B. W. Balleine, 1994）。在这项研究中，苯二氮卓类激动剂咪达唑仑被发现以类似的方式控制工具作用。咪达唑仑（1 mg/kg）提高了未剥夺训练大鼠的奖励乐器表现，但在测试前再次暴露于咪达唑仑下的乐器结果时，只提高了大鼠在灭绝中的表现。这种在咪达唑仑下再次暴露的效果并没有转移到在食物剥夺下进行的测试中，这表明它不是由药物引起的饥饿产生的。最后，在饥饿训练的动物中，咪达唑仑被发现可以阻止由食物剥夺减少引起的结果贬值，这表明咪达唑仑和食物剥夺通过共同的基础影响结果价值。
It has been argued that the control of instrumental action by motivational states is indirect, being mediated by the effects these states have on the incentive value of the instrumental outcome (A. Dickinson & B. W. Balleine, 1994). In this study, the benzodiazepine agonist midazolam was found to control instrumental action in a similar manner. Midazolam (1 mg/kg) increased rewarded instrumental performance in rats trained undeprived but only elevated performance in extinction when rats were reexposed to the instrumental outcome under midazolam before the test. This effect of reexposure under midazolam did not transfer to a test conducted under food deprivation, suggesting that it was not produced by drug-induced hunger. Finally, in animals trained hungry, midazolam was found to block outcome devaluation induced by a reduction in food deprivation, indicating that midazolam and food deprivation affect outcome value via a common substrate.