Preparation of Hydroxyapatite Microspheres by Interfacial Reaction in a Multiple Emulsion
Preparation of Hydroxyapatite Microspheres by Interfacial Reaction in a Multiple Emulsion
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DOI：
10.2109/jcersj2.115.888
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发表时间：
2007-12
影响因子：
1.1
通讯作者：
I. Kimura;Tatsuro Honma;R. Riman
中科院分区：
文献类型：
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作者：
I. Kimura;Tatsuro Honma;R. Riman
采用多重乳液界面反应法制备空心羟基磷灰石（HAp）微球。复合乳液为W/O/W型乳液，内水相为磷酸氢二钾溶液，油相为环己烷，外水相为硝酸钙溶液。通过热力学计算绘制了Ca（NO_3）_2-K_2HPO_4-H_2O体系的相图，并用于模拟复乳中的化学过程，确定了实验条件。在初始pH为12.0下合成单相HAp。通过电感耦合等离子体光谱法测量具有Ca/P比的HAp对应于1.49。产物由直径为0.5 ~ 2 μm的微球组成。每个微球由长径比为2.5-10的针状颗粒组成，短轴长度约为20 nm。
Interfacial reaction in a multiple emulsion, was carried out with the aim of preparing hollow hydroxyapatite (HAp) microspheres. The multiple emulsion was a W/O/W emulsion, made of dipotassium hydrogen phosphate solution as an inner aqueous phase, cyclohexane as an oil phase, and calcium nitrate solution as an outer aqueous phase. The phase diagrams of Ca(NO3)2-K2HPO4-H2O system were drawn by thermodynamic computations and used to simulate the chemical process in a multiple emulsion for determining the experimental conditions. Single phase HAp was synthesized at an initial pH of 12.0. HAp with a Ca/P ratio was measured by inductively coupled plasma spectroscopy to correspond to 1.49. The product was composed of microspheres of 0.5 to 2 μm in diameter. Each microsphere was composed of acicular particles with an aspect ratio of 2.5-10 with a short axis length of about 20 nm.