Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections
Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections
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DOI：
10.1128/iai.73.7.4395-4398.2005
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发表时间：
2005-07-01
影响因子：
3.1
通讯作者：
Ramphal, R
中科院分区：
文献类型：
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作者：
Arora, SK;Neely, AN;Ramphal, R
在这项研究中，我们使用遗传定义的鞭毛突变体测试了铜绿假单胞菌中鞭毛运动、鞭毛蛋白结构及其糖基化的贡献。所有突变体及其亲本菌株均在烧伤小鼠感染模型中进行了测试。鞭毛的运动性和糖基化似乎是该模型中鞭毛介导的毒力的重要决定因素。这是第一份在烧伤小鼠感染模型中测试基因定义的铜绿假单胞菌鞭毛变体的报告。
In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.