Impact of dietary exposure to food contaminants on the risk of Parkinson's disease
Impact of dietary exposure to food contaminants on the risk of Parkinson's disease
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DOI：
10.1016/j.neuro.2008.03.001
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发表时间：
2008-07-01
期刊：
影响因子：
3.4
通讯作者：
Grandjean, Philippe
中科院分区：
文献类型：
--
作者：
Petersen, Maria Skaalum;Halling, Jonrit;Grandjean, Philippe
本研究的目的是调查帕金森病（PD）与饮食暴露于多氯联苯（PCBs）和甲基汞（MeHg）在一个社区的暴露水平增加的关联。在法罗群岛的病例对照研究中，共检查了79例经临床验证的特发性PD病例和154例按性别和年龄匹配的对照。采集血液和头发样本，并进行问卷调查，记录有关居住地、饮食习惯、吸烟史和职业暴露于溶剂、农药和金属的终生信息。使用无条件和条件logistic回归分析估计相关暴露变量的比值比（OR）和95%置信区间（CI）。在成年期，鲸鱼肉和鲸脂的饮食摄入量增加的OR具有统计学意义。职业暴露于溶剂、农药和金属的OR也表明PD的风险增加。目前血清中西格玛多氯联苯和相关污染物的浓度表明，尽管只有乙型六氯环己烷（乙型六氯环己烷）具有统计学意义，但OR值略有增加。在成年生活中鲸鱼肉和鲸脂的摄入量增加与PD显着相关，从而表明以前暴露于海洋食品污染物和PD的发展之间存在正相关。(C)2008年爱思唯尔公司All rights reserved.
This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of Sigma PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD. (C) 2008 Elsevier Inc. All rights reserved.