Effects of the Na(+)/H(+) exchanger monensin on intracellular pH in astroglia.
Effects of the Na(+)/H(+) exchanger monensin on intracellular pH in astroglia.
复制标题
Na( )/H( ) 交换剂莫能菌素对星形胶质细胞内 pH 值的影响。
DOI：
10.1016/s0006-8993(00)02822-5
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发表时间：
2000
期刊：
影响因子：
2.9
通讯作者：
Sokoloff,L
中科院分区：
文献类型：
--
作者：
Itoh,Y;Law,MJ;Sokoloff,L
哇巴因只部分阻断Na+/H+交换器莫能菌素对星形胶质细胞葡萄糖利用的刺激作用。目前的研究表明，莫能菌素还可以提高星形胶质细胞内的pH。由于pH升高刺激磷酸果糖激酶活性，哇巴因不敏感的部分大脑葡萄糖利用(CMRglc)似乎是由于细胞内碱化刺激糖酵解。
Stimulation of astroglial glucose utilization by the Na+/H+exchanger monensin is only partially blocked by ouabain. The present studies show that monensin also raises intracellular pH in astroglia. Because increased pH stimulates phosphofructokinase activity, the ouabain-insensitive portion of the stimulation of cerebral glucose utilization (CMRglc) appears to be due to stimulation of glycolysis by intracellular alkalinization.